University of Utah Research Foundation

Neurocrine Biosciences, Inc.

Glaxo Wellcome Spa

Curza Global, LLC

Escape Bio, Inc.

Sb Pharmaco Puerto Rico Inc.

Fabio Maria Sabbatini

Romano Di Fabio

Jacob Bradley Schwarz

Albert W Garofalo

Daniele Andreotti

Stéphane De Lombaert

Yves St-Denis

Ryan E Looper

Alessandra Pasquarello

Paul R Sebahar

Travis J Haussener

Carmela Napolitano

Hariprasada R Kanna Reddy

Charles Testa

Claudia Beato

Marco Migliore

Federica Budassi

Romano Di-Fabio

Benlsaac C Tresco

Seth Grant

Elena Serra

Silvia Bernardi

The invention is directed to compounds that are active as antibacterial agents. The invention compounds are active against gram-positive and gram-negative bacteria and can be used to treat infections caused by gram-positive and gram-negative bacteria. Also disclosed are processes and intermediates for making the compounds.

Antimicrobial compounds and methods

The present invention is directed to indazole and azaindazole compounds which are inhibitors of LRRK2 and are useful in the treatment of CNS disorders.

Indazoles and azaindazoles as LRRK2 inhibitors

The present invention provides compounds of formula (I) including stereoisomers, prodrugs and pharmaceutically acceptable salts or solvates thereof to processes for their preparation, to pharmaceutical compositions containing them and to their use in the treatment of conditions mediated by corticotrophin-releasing factor (CRF).

Condensed N-heterocyclic compounds and their use as CRF receptor antagonists

Compounds of formula (I) or salt, or metabolically labile ester thereof wherein R represents a group selected from halogen, alkyl, alkoxy, amino, alkylamino, dialkylamino, hydroxy, trifluoromethoxy, nitro, cyano, SO R or COR wherein R represents hydroxy, methoxy, amino, alkylamino or dialkylamino; m is zero or an integer 1 or 2; R represents cyano or the group (CH )nCN, &mdash;CH&boxH;CHR , CH )nNHCOCH R or O(CH )pNR R ; R represents cyano or the group COR ; R represents alkoxy or a group NHCOR ; R and R each represent independently hydrogen or alkyl, or R and R together with the nitrogen atom to which they are attached represent a heterocyclic group, or R is hydrogen and R is the group COR ; R represents an alkoxy, amino or hydroxyl group; R represents a hydrogen atom or optionally substituted alkyl, alkoxy, aryl, or heterocyclic group; R is the group R or the group NR R wherein R represents hydrogen or alkyl group; R represents optionally substituted alkyl, aryl, heterocyclic or cycloalkyl group; n is zero or an integer from 1 to 4, p is an integer from 2 to 4, processes for their preparation and to their use in medicine.

Tetrahydroquinoline derivatives as EAA antagonists

Growing community of inventors

Verona, Italy

Fabio Maria Sabbatini