Farmitalia Carlo Erba

Pharmacia & Upjohn

Fabio Corradi

Marina Ciomei

Carlo Battistini

Luigia Gozzini

Alberto Bardelli

Paolo Comoglio

Roberto De Castiglione

Patrizia Giordano

Mauro Galantino

Isabella Molinari

Sabrina De Rosa

The present invention relates to peptides and peptidomimetic compounds and pharmaceutical compositions containing them as useful pharmacological agents in the control or treatment of proliferative diseases such as cancer, against tumor growing and/or tumoral metastasis, and psoriasis and in the control or treatment of inflammatory, allergic, autoimmune, viral, and cardiovascular diseases. These new compounds have the unique property to inhibit the recognition of several phosphotyrosine containing motifs within all the cellular receptors and cytosolic transducers by a wide spectrum of SH2 domains contained in cytosolic transducers and other effector proteins laying along different pathways of the signal transduction process and with a particularly high affinity for the SH2 domain of the adaptor transducer Grb2, a key element along the pathway to mitogenesis and motogenesis, this last activity leading to invasiveness and to metastasis. The invention also relates to methods for production of the compounds and methods of treatment employing the compounds.

Peptide antagonists of cellular mitogenesis and motogenesis and their therapeutic use

Irreversible peptide ligands for bombesin receptors, their use, and

Growing community of inventors

Milan, Italy

Fabio Corradi