Eniricerche S.p.a.

Enichem S.p.a

Sclavo Spa

Fabio Bonelli

Antonio S Verdini

Antonello Pessi

Adriano Bernardi

Romano Di Trapani

Franco Cardinali

Diana Boraschi

Stefano Censini

Polypeptide useful for the preparation of antimalarial vaccines and of diagnostic kits for the detection of antisporozoite antibodies in clinical samples of malariated persons, constituted by: a synthetic peptide, which repeates the region I of P. falciparum and by a variable number of repetitive tetrapeptide units of CS protein of P. falciparum linked to each other by an amidic bond between the tail proline of I region and the head asparagine of the first tetrapeptide.

Polypeptide useful for the preparation of antimalarial vaccines and of

Synthetic polypeptides constituted by at least two consecutive repeating units of (Asn-Asn-Pro) sequence are powerful immunogens in test animals. The formed antibodies recognize both the synthetic polypeptides and the immuno-dominant epitope of the circumsporozoitic protein of Plasmodium falciparum. Said polypeptides, which can be obtained in pure form, are particularly useful for the preparation of antimalarial vaccines and of diagnostic kits for the determination of malarial affections.

Sequential polypeptides endowed with immunological activity

Immunologically active polypeptide composition constituted by polypeptides having the formula:

Polypeptidic composition useful for the preparation of antimalarial

Synthetic peptides constituted by at least two repeating, consecutive units of asparaginyl-proline (Asn-Pro).sub.n sequence, are described. The peptides are powerful immunogens, capable of inducing in laboratory animals the formation of a high concentration of antibodies capable of reacting both with the (Asn-Pro).sub.n peptides, and with the immunodominant epitope of the circumsporozoite protein of Plasmodium falciparum. The peptides, which can be obtained in a pure form by chemical synthesis, are particularly useful for preparing antimalarial vaccines and diagnostic kits for the determination of malaria in man.

Synthetic, immunologically active peptides useful for the preparation of

Synthetic peptides consisting of at least two consecutive repeating units of the sequence (Ala-Asn-Asn-Pro) are powerful immunogens in experimental animals. The antibodies which form recognize both said synthetic peptides and the immunodominant epitope of the circumsporozoitic peptide of Plasmodium falciparum. Said peptides, obtainable in pure form, are particularly useful for preparing antimalarial vaccines and diagnostic kits for the determination of malarial affections.

Immunologically active synthetic peptides useful for preparing an

Immunologically active polypeptides constituted, towards the N-terminated end, by an Asn-Val-Asp-Pro-Asn-Ala-Asn-Pro sequence repeated three times and, towards the C-terminated end, by at least three quadruplets with an Asn-Ala-Asn-Pro sequence, linked with each other by means of an amidic bond between the end proline of the first sequence, and the initial asparagine of the first quadruplet. Said polypeptides reproduce nearly exactly the sequential structure of the circumsporozoite protein of P. falciparum, and are useful for the preparation of antimalarial vaccines and of diagnostic kits for the detection of antisporozoite antibodies in clinical samples of malariated persons.

Immunologically active polypeptides useful for the preparation of

New partially retro-inverted tuftsin analogues of general formula I ##STR1## wherein R represents the side-chain of the amino acids threonine, methionine or leucine

Partially retro-inverted tuftsin analogues, method for the preparation

Hexapeptides with vasodilating and hypotensive activity are described corresponding to the formula: ##STR1## wherein:

Retro-inverso hexapeptide neurotensin analogs, process for their

Pharmacologically active, partially retro-inverso, neurotensin-like peptides lasting longer than the natural hormone, corresponding to the formula ##STR1## wherein R.sup.1 and R.sup.2 are straight or branched (C.sub.1 -C.sub.7) alkyl radicals. The new compounds are useful as vasodilating and hypotensive agents.

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Rome, Italy

Fabio Bonelli