West Pharmaceutical Services Drug Delivery & Clinical Research Centre Limited

Other

Asta Medica, Aktiengesellschaft

Fabio Bignotti

Paolo Ferruti

Stanley Stewart Davis

Martin Charles Garnett

Elisabetta Ranucci

Wu Lin

Maurizio Penco

Fiona Caroline Maclaughlin

PEG-chitosan conjugates comprising chitosan and polyethylene glycol moieties or derivatives thereof which are bonded together and their use in medicine is described. In one embodiment, the conjugate comprises a chitosan moiety or a derivative thereof and a polyethylene glycol moiety or a derivative thereof which are bonded together via the amino function on the chitosan by the use of an activated chitosan species. In another embodiment, the conjugate comprises a chitosan moiety or a derivative thereof and a polyethylene glycol moiety or a derivative thereof which are bonded together, the chitosan portion of the conjugate having a molecular weight in the range of from 10 kilodaltons to 1000 kilodaltons.

Conjugate of polyethylene glycol and chitosan

A process for attaching a polyethylene glycol compound to a macromolecule to prepare a conjugate or adduct between the polyethylene glycol compound and the macromolecule is described. The process comprises the steps of (1) preparing an activated PEG or an activated PEG derivative by incorporating an acrylic ester, an acrylic thioester or an acrylamido group into the PEG or PEG derivative; (2) reacting the activated PEG or PEG derivative with a macromolecular material comprising one or more sulphydryl groups, primary amino groups and/or secondary amino groups and (3) recovering the conjugate of the PEG or PEG derivative and the macromolecular material.

Method for attaching polyethylene glycol to macromolecules

A composition for delivering a biologically active polyanionic molecule comprising a linear polymer with a backbone comprising amido and tertiary amino groups arranged regularly on the backbone and biologically active polyanionic molecule bound to the polymer. Preferably, the linear polymer comprises a poly(amidoamine). Preferably, the biologically active polyanionic molecule is a nucleic acid, more preferably a DNA. The compositions are useful for delivering nucleic acids to a cell in a cell transformation, transfection or gene therapy method.

Polymer composition for delivering a nucleic acid or derivative thereof

High molecular weight polyesterpolycarbonates and the use thereof for

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Brescia, Italy

Fabio Bignotti