Institute for Research in Biomedicine

Humabs Biomed Sa

Fabio Benigni

Davide Corti

Fabio Grassi

Matteo Samuele Pizzuto

Lisa Perruzza

The instant disclosure provides antibodies and antigen-binding fragments thereof that are specific forand, in certain embodiments, are capable of neutralizing ainfection in a subject. In certain embodiments, the antibody or antigen binding fragment comprises an IgA antibody, such as, for example, a secretory IgA antibody. Also provided are pharmaceutical compositions comprising a disclosed antibody or antigen-binding fragment. Methods of using the antibodies, antigen-binding fragments, and compositions to treat or prevent ainfection in a subject are also provided. In certain embodiments, recombinant secretory IgA antibodies of the instant disclosure are administered orally to a subject having or at risk of developing ainfection.

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Bellinzona, Switzerland

Fabio Benigni