Fondazione Istituto Italiano Di Tecnologia

Politecnico Di Milano

Istituto Don Calabria—ospedale Classificato Sacro Cuore

Fabio Benfenati

Roberto Cingolani

Alberto Diaspro

Guglielmo Lanzani

Francesco Difato

Chiara Bertarelli

Grazia Pertile

Bruno Torre

Giuseppe Maria Paterno′

Mattia Lorenzo DiFrancesco

Diego Ghezzi

Elisabetta Colombo

Maria Rosa Antognazza

Maurizio Mete

Letizia Colella

Giuliano Freddi

Francesco Lodola

Josè Fernando Maya-Vetencourt

Ilaria Donelli

Axel Blau

Giuseppe Maria Paterno'

Mattia Lorenzo Difrancesco

Compounds have a formula (1) wherein Y and Z are independently O, N, P; R, R, R, R, where present, are independently H. Optionally substituted C-Calkyl, O, or R and Rand/or Rand Rform, together with the atom Y and/or Z to which they are attached, a 3-14 membered ring. The compounds optionally contain one or more additional heteroatoms selected from O, N, and S, optionally substituted. Compositions include such compounds and the medical uses utilize such compounds.

Photochromic compounds for use in the treatment of eye disorders

Devices are provided for inhibiting the electrical activity of an excitable cell through the application of a pulse of light which includes a substrate and a photoreactive film both of non-conducting material and laid directly on one another, in which the photoreactive film includes a layer of semiconductor polymer material and has an interface surface which can be placed in contact with an excitable cell and an electrolyte solution. After absorbing light, when placed in contact with the excitable cell and the electrolyte solution, the photoreactive film produces a potential difference across this interface surface which is capable of giving rise to hyperpolarization of the membrane of the excitable cell. Methods of inhibiting the electrical activity of excitable cells using such devices are also provided.

Organic devices for the photoinhibition of excitable cells

Growing community of inventors

Genoa, Italy

Fabio Benfenati