Euticals Prime European Therapeutical Spa

Fabio Benedetti

Claudio Gianluca Pozzoli

Claudio Giordano

A process is described for the preparation of arylpyridine compounds by aryl-aryl cross-coupling reactions between a halopyridine and an arylmagnesium halide carried out in the presence of a catalytic amount of a zinc salt and a catalytic amount of palladium. The zinc salt is preferably selected from ZnCl , ZnBr and/or Zn(OAc) , while the palladium is preferably used in the form of Pd(PPh ) or Pd(OAc) &plus;4 PPh . The reaction can also be carried out in the presence of bidentate phosphines, such as, for example, 1,3-bis(diphenylphosphine)propane or 1,4-bis(diphenylphosphine)-butane. It is thus possible to obtain molar yields higher than 97% (calculated relative to the halopyridine) and a catalyticity of more than 2000.

Growing community of inventors

Cremella, Italy

Fabio Benedetti