Centre National De La Recherche Scientifique

Institut National De La Sante Et De La Recherche Medicale

Fabienne Sylvie Pelle

Daniel Scherman

Serge Maitrejean

Didier Gourier

Corinne Chaneac

Jean-Pierre Jolivet

Michel Bessodes

Quentin Le Masne De Chermont

The invention relates to using persistent luminescence nanoparticles, functionalised if necessary, in the form of an diagnosis agent for an in vivo optical imaging. Said nanoparticles are preferably consist of a compound selected from a group comprising (1) silicates, aluminates, aluminosilicates, germanates, titanates, oxysulphides, phosphates and vanadates, wherein said compounds contain at least one type of metal oxide, (2) the sulphides comprise at least one metal ion selected from zinc, strontium and calcium, and (3) metal oxides, wherein said compounds is doped with at least one rare earth ion, and possibly with at least one transition metal ion. In a preferred embodiment, the diagnosis agent is used for an organism vascularization imaging. A method and kit for detecting or quantifying in vitro a substance of biological or chemical interest in a sample by using said pre-functionalised nanoparticles are also disclosed.

Persistent luminescence nanoparticles used in the form of a diagnosis agent for in vivo optical imaging

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Colombes, France

Fabienne Sylvie Pelle