Sanofi-aventis

Roussel Uclaf

Aventis Pharma S.a.

Sanofi

Fabienne Pilorge

Jean-Marie Ruxer

Joachim Brendel

Klaus Wirth

Michael Wagner

Patrick Mailliet

Fabienne Thompson

Luc Bertin

Heinrich Englert

Jean-Pierre Demoute

Stefan Peukert

Didier Babin

Marc D Benoit

Maria Mendez-Perez

Hervé Minoux

Chantal Carrez

Didier Benard

Nicole Reinier

Stephane Hourcade

Hélène Goulaouic

Peter Hamley

Francois Vallee

Thierry Gouyon

Stéphane Hourcade

Maria Mendez-perez

The present invention relates to compounds of formula (I): wherein R1, R, R', L, Het, p and p&#x2032; are as defined herein, compositions containing them, and their use as medicinal products.

Fluorene derivatives, compositions containing the same and use thereof as inhibitors of the protein chaperone HSP 90

The invention relates to compounds of formula I in which R1, R2, R3, R4, R5, R6 and X have the meanings stated in the claims. The compounds are particularly suitable as antiarrhythmic active ingredients, in particular for the treatment and prophylaxis of atrial arrhythmias, for example atrial fibrillation (AF) or atrial flutter.

Substituted heterocycles, their use as medicament, and pharmaceutical preparations comprising them

The invention relates to compounds of formula I in which A, R1, R2, R3, R4, R5, R6, R7 and n have the meanings stated in the claims. The compounds are particularly suitable as antiarrhythmic active ingredients, in particular for the treatment and prophylaxis of atrial arrhythmias, for example atrial fibrillation (AF) or atrial flutter.

This invention relates to derivatives of 4-(benzimidazol-2-yl)fluorene and 4-(azabenzimidazol-2-yl)fluorene, to pharmaceutical compositions comprising such derivatives, and to methods of treatment of disorders related to Hsp90 protein activity, comprising administering such derivatives.

Fluorene derivatives, composition containing said derivatives and the use thereof

A compound selected from the group consisting of all stereoisomeric forms and mixtures thereof of a compound of the formula ##STR1## wherein Y and Z are individually selected from the groups consisting of hydrogen, halogen, --CF.sub.3, alkyl, alkoxy and alkylthio of 1 to 8 carbon atoms and aryl, aryloxy and arylthio of up to 14 carbon atoms optionally substituted with at least one member of the group consisting of halogen, hydroxy optionally esterified etherified, --CF.sub.3 and alkyl of 1 to 8 carbon atoms and R is alkyl of 1 to 8 carbon atoms or the remainder of a pyrethrinoid alcohol having excellent pesticidal properties and their preparation and intermediates.

Esters of 2,2-dimethyl-3-[(2,2-difluoro-cyclopropylidene)

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Paris, France

Fabienne Pilorge