Teva Pharmaceutical Industries Limited

Diasource Immunoassays S.a.

Fabienne Mathieu

Henri Wantier

Dominique Delacroix

Marc Baudrihaye

Frederic Lin

Michel Anciaux

Martin Poncelet

Frédéric Lin

The invention concerns a process for the production of a hybridoma, and of a monoclonal antibody or fragments thereof able to recognize 25-hydroxyvitamin Dand 25-hydroxyvitamin D

Process for the production of a hybridoma and antibody obtained therefrom, able to recognize more than one vitamin D metabolite

Microspheres which are a matrix of a biocompatible and biodegradable polymer which is soluble in an organic solvent which is immiscible in water, within which a water-soluble substance is uniformly distributed, and wherein the residual level of toxic solvent in the microspheres is lower than 1.5% by weight, progressively and continuously releases the substance over a period of at least 8 days when the microspheres are placed in an aqueous physiological environment, with a reduced or substantially absent first phase of accelerated release. A process for producing such microspheres is provided.

Microspheres for the controlled release of water-soluble substances and

The subject of the present invention is a process for preparing microparticles of the microsphere type of a water-soluble substance and a biocompatible and biodegradable polymer controlling the kinetics of release of the said substance consisting of a matrix of the said polymer within which the said water-soluble substance is regularly dispersed, characterized in that

Preparation of microparticles for controlled release of water-soluble

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Nivelles, Belgium

Fabienne Mathieu