Centre National De La Recherche Scientifique

Universite Claude Bernard – Lyon1

Nh Theraguix

Total Sa

Universite Lyon 1

Inoventeam

Centre National De La Recherche Gantifote—cnrs—

Totalenergies Onetech

Université Claude Bernard Lyon I

Fabien Rossetti

Olivier Tillement

François Lux

Antoine Vanlaer

Christian Hurtevent

Salima Baraka-Lokmane

Arthur Marais

John-Richard Ordonez-Varela

Matteo Martini

Mahmoud Ould-Metidji

François Ghillebaert

Florian Lepoivre

Clélia Mathieu

Vu-Long Tran

Myleva Dahan

Mahmoud Ould Metidji

Vivek Thakare

Anatole Collet

Vu Long Tran

Francois Ghillebaert

The present invention relates to the field of nanovectors for the delivery of active substances in the body, in particular for the treatment of tumours. In particular, the use of these nanovectors makes it possible to improve the pharmacokinetics of the active substances with a more selective delivery, for example in the tumour tissues.

Nanovectors and uses

The invention relates to a method for synthesizing ultrasmall silica nanoparticles, useful in particular for diagnostics and/or therapy. More specifically, a method for synthesizing silica nanoparticles, said method comprising the mixing of at least one silane which is negatively charged at physiological pH with at least one silane which is neutral at physiological pH, and/or at least one silane which is positively charged at physiological pH, wherein: &#x2014;the molar ratio A of neutral silane(s) to negatively charged silane(s) is defined as follows: 0&#x2264;A&#x2264;6, &#x2014;the molar ratio B of positively charged silane(s) to negatively charged silane(s) is defined as follows: 0&#x2264;B&#x2264;5, &#x2014;the molar ratio C of neutral and positively charged silanes to negatively charged silane(s) is defined as follows: 0&#x3c;C&#x2264;8. The invention also relates to the obtained ultrasmall silica nanoparticles.

Method for synthesizing silica nanoparticles

The use, as markers of petroleum products, crude oils, biofuels or lubricants, of rare earth complexes or one of the constituents thereof chosen from rare earth ligands or salts, being capable of forming a rare earth complex after the addition of a developing solution. Preferably, the rare earth complex can be detected by time-resolved fluorescence. Also, a marking method and a method for detecting a rare earth complex as a marker of petroleum products, crude oils, biofuels or lubricants.

Use of rare earth complexes as markers of petroleum products, crude oils, biofuels or lubricants

A copolymer containing a unit including an optionally neutralized styrene sulphonic acid unit and a unit containing at least one optionally neutralized (poly)carboxylic acid unit or a (poly)amido-amine unit, to inhibit or slow the formation of sulphide deposits during the extraction of gas or oil. It also relates to a method to inhibit or slow the formation of sulphide deposits during the extraction of gas or oil, including the injection of a fluid containing the abovementioned copolymer into a wellbore, a subterranean formation or a gas or oil well.

Use of a copolymer made from styrene sulphonic acid to inhibit or slow the formation of sulphide deposits

Growing community of inventors

Villeurbanne, France

Fabien Rossetti