Mutabilis

Fab Pharma S.a.s.

Hivih

Fabien Faivre

Sophie Chasset

Francis Chevreuil

Christophe Simon

Julie Brias

Audrey Caravano

Sophie Vomscheid

Frédéric Le Strat

Julien Barbion

Sébastien Richard

Nicolas Lecointe

Benoît Ledoussal

Chrystelle Oliveira

Géraldine Le Fralliec

Vincent Gerusz

Alexis Denis

Mayalen Oxoby

Benoit Ledoussal

Yannick Bonvin

Dmytro Atamanyuk

Rémi Lebel

Benôit Ledoussal

Sophie Briet

Frédéric Le-Strat

Laurence Farescour

Sophia Briet

A compound of formula (I) or a racemate, an enantiomer, a diastereoisomer, a geometric isomer or a pharmaceutically acceptable salt thereof, and its use as antibacterial agent.

Heterocyclic compounds and their use in preventing or treating bacterial infections

The present invention relates to heterocyclic compounds, their process of preparation, pharmaceutical compositions comprising these compounds and use thereof, optionally in combination with other antibacterial agents and/or beta-lactam compounds, for the prevention or treatment of bacterial infections. The present invention also relates to the use of these compounds as &#x3b2;-lactamase inhibitors and/or as antibacterial agents.

The invention relates to the compounds (I) and their acids and bases salts: wherein: Formula (I) the dotted line indicates a double bond; X is N or C&#x2014;Rand Y is N or C&#x2014;R, X and Y not being simultaneously N; A is selected from the group consisting of phenyl, naphthyl and (5-11) membered monocyclic or bicyclic unsaturated cycle or heterocycle possibly substituted as defined in the application, and A can also comprise either a further (4-7) membered heterocycle, said heterocycle being a monocycle, fused, saturated or unsaturated, the polycyclic system then comprising up to 14 members and up to 5 heteroatoms selected from N, O and S; B is selected from the group of substituents as defined in the application, or B is a 4 or (6-10) membered mono or bicyclic saturated or unsaturated heterocycle containing 1-3 heteroatoms selected from N, O and S, linked by a carbon atom, and possibly substituted as defined in the application; Ris Hydrogen or a substituent as defined in the application; Ris Hydrogen or Halogen; their preparation, their use in the antibacterial prevention and therapy, alone or in association with antibacterials, antivirulence agents or drugs reinforcing the host innate immunity, and pharmaceutical compositions and associations containing them. 

Heteroaromatic derivatives and their use as pharmaceuticals

The present invention relates to compounds, their use in the treatment or the prevention of viral disorders, including HIV.

Inhibitors of viral replication, their process of preparation and their therapeutical uses

The invention relates to a novel hydroxyphenyl compound, to the preparation of the compound and intermediates used therein, to the use of the compound as an antibacterial medicament and pharmaceutical compositions containing the compound.

Antibacterial hydroxyphenyl compound

Growing community of inventors

Drancy, France

Fabien Faivre