Covagen Ag

Fabian Buller

Dragan Grabulovski

Julian Bertschinger

Richard Woods

Patricia Henne

Ulrike Von Der Bey

Simon Brack

Isabella Attinger-Toller

Susann König-Friedrich

Ulrich Wüllner

Michela Silacci

Irene Zbinden

Kristina Klupsch

Helen Hachemi

Roger Santimaria

Ulrich WÜLLNER

Susann KÖNIG-Friedrich

The present invention relates to a polypeptide binding to human serum albumin and comprising or consisting of an amino acid sequence selected from the group consisting of: (a) GVTLFVALYDY(X)(X)(X)(X)(X)(X)D(X)SFHKGEKFQIL(X)(X)(X)(X)(X)G(X)(X)W(X)(X)RSLTTG(X)(X)G(X)IPSNYVAPVDSIQ (SEQ ID NO: 1), wherein (X) is A, V, I, L, M, G, P, S, T, N, Q, C, R, H, K, D or E; (X) is R, H, K, A, V, I, L, M, G, P, S, T, N, Q or C; (X) is R, H, K, S, T, N, Q, C, F, Y, W, A, V, I, L, M, G or P; (X) is S, T, N, Q, C, A, V, I, L, M, G, P, R, H, K, F, Y, W, D or E; (X) is S, T, N, Q, C, D, E, F, Y, W, A, V, I, L, M, G, P, R, H or K; (X) is F, Y, W, A, V, I, L, M, G, P, R, H, K, S, T, N, Q or C; (X) is A, V, I, L, M, G, P, R, H or K; (X) is S, T, N, Q, C, D or E; (X) is S, T, N, Q, C, D, E, A, V, I, L, M, G, P, F, Y or W; (X) is A, V, I, L, M, G or P; (X) is F, Y, W, R, H or K; (X) is S, T, N, Q, C, F, Y or W; (X) is F, Y, W, R, H, K, S, T, N, Q, C, D, E, A, V, I, L, M, G or P; (X) is F, Y, W, A, V, I, L, M, G or P; (X) is D, E, A, V, I, L, M, G or P; (X) is A, V, I, L, M, G or P; (X) is D, E, A, V, I, L, M, G, P, R, H or K; (X) is S, T, N, Q, C, A, V, I, L, M, G or P; (X) is F, Y, W S, T, N, Q or C; and (b) an amino acid sequence which is at least 90% identical to the amino acid sequence of (a), wherein the identity determination excludes amino acid positions (X) to (X).

Human serum albumin binding compounds and fusion proteins thereof

The present invention relates to a polypeptide binding to human serum albumin and comprising or consisting of an amino acid sequence selected from the group consisting of: (a) GVTLFVALYDY(X)(X)(X)(X)(X) (X)D(X)SFHKGEKFQIL(X)(X)(X)(X)(X)G(X)(X)W(X)(X)RSLTTG(X)(X)G(X)IPSNYVAPVDSIQ (SEQ ID NO: 1), wherein (X) is A, V, I, L, M, G, P, S, T, N, Q, C, R, H, K, D or E; (X) is R, H, K, A, V, I, L, M, G, P, S, T, N, Q or C; (X) is R, H, K, S, T, N, Q, C, F, Y, W, A, V, I, L, M, G or P; (X) is S, T, N, Q, C, A, V, I, L, M, G, P, R, H, K, F, Y, W, D or E; (X) is S, T, N, Q, C, D, E, F, Y, W, A, V, I, L, M, G, P, R, H or K; (X) is F, Y, W, A, V, I, L, M, G, P, R, H, K, S, T, N, Q or C; (X) is A, V, I, L, M, G, P, R, H or K; (X) is S, T, N, Q, C, D or E; (X) is S, T, N, Q, C, D, E, A, V, I, L, M, G, P, F, Y or W; (X) is A, V, I, L, M, G or P; (X) is F, Y, W, R, H or K; (X) is S, T, N, Q, C, F, Y or W; (X) is F, Y, W, R, H, K, S, T, N, Q, C, D, E, A, V, I, L, M, G or P; (X) is F, Y, W, A, V, I, L, M, G or P; (X) is D, E, A, V, I, L, M, G or P; (X) is A, V, I, L, M, G or P; (X) is D, E, A, V, I, L, M, G, P, R, H or K; (X) is S, T, N, Q, C, A, V, I, L, M, G or P; (X) is F, Y, W, S, T, N, Q or C; and (b) an amino acid sequence which is at least 90% identical to the amino acid sequence of (a), wherein the identity determination excludes amino acid positions (X) to (X).

Growing community of inventors

Zurich, Switzerland

Fabian Buller