University of Virginia Patent Foundation

The University of North Carolina at Chapel Hill

Hemosonics LLC

F William Mauldin, Jr

John Alexander Hossack

William F Walker

Francesco Viola

Kevin Owen

Shiying Wang

Alexander L Klibanov

Caterina Maria Gallippi

Elizabeth Bronwyn Herbst

Olgha Davis

Mansoor Haider

Abhay V Patil

Elizabeth G Loboa

An apparatus can be used to generate acoustic imaging pulse sequences and receive corresponding echoes elicited by the acoustic imaging pulse sequences. An acoustic radiation force (ARF) pulse sequence can be generated to agitate a contrast medium in a tissue region between the acoustic imaging pulse sequences. A decorrelation between images corresponding to the received echoes can be determined. A weighting map can be applied to an image to weight a region of the image corresponding to a spatial location of the contrast medium using the determined decorrelation. In an example, the receiving of corresponding echoes elicited by the acoustic imaging pulse sequences can include receiving acoustic energy having a range of frequencies offset from a fundamental frequency associated with the acoustic imaging pulse sequences. An acoustic imaging pulse sequence can include a pulse having an inverted amplitude envelope with respect to another pulse included in the sequence.

Ultrasound contrast agent decorrelation-based signal separation

Method and systems for of evaluating a mechanical property of a material by applying force to the material sufficient to physically displace a portion of the material, measuring displacement of the material, adaptively adjusting the force when the displacement measured is not within a predetermined range of displacement values, wherein the force is increased or decreased depending upon whether the measured displacement is below or above the predetermined range, respectively, and computing a mechanical property value resultant from the displacement of the material.

Ultrasound-based method and related system to evaluate hemostatic function of whole blood

An ultrasonic transducer element can configured to generate ultrasonic energy directed into tissue of a subject and configured to receive a portion of the ultrasonic energy reflected by a target located within the tissue. The ultrasonic transducer can include a surface configured to provide or receive the ultrasonic energy, the surface including an area of greater than or equal to about 4&#x3bb;, or the ultrasonic transducer element can be included in an array having a spacing between at least two adjacent ultrasound elements of less than or equal to about &#xbd;&#x3bb;, and the array comprising an aperture that is at least approximately symmetrical in two axes. A three-dimensional representation of one or more of a location, shape, or orientation of at least a portion of the target can be presented via the display.

Bone surface image reconstruction using ultrasound

An ultrasound system and method that can include: a receive beamformer configured to receive signals from a transducer; a processor coupled to the receive beamformer, the processor configured to: analyze echo data reflected from a region of interest, the echo data elicited by a transmitted pulse sequence; using the echo data, determine a central tendency of a signal magnitude from regions of adherent microbubbles over time within the region of interest; determine a time series of the signal magnitude; using the time series, determine an initial signal magnitude parameter; obtain a saturated signal parameter and a residual signal parameter using the time series; and determine a relative indication of information indicative of the residual signal magnitude versus the saturated signal magnitude.

System and method for binding dynamics of targeted microbubbles

Ultrasound apparatus or techniques can include obtaining reflected ultrasound echo information, which can be used to construct a two-dimensional or three-dimensional representation of an at least approximately specular reflected target, such as bone. In an example, echo information can be obtained from spatially-overlapping tissue regions, such as using one or more of an array of ultrasonic transducers, or mechanically-scanning one or more ultrasonic transducers. In an example, one or more of a deformable housing or a deformable coupling pad can be used, such as to couple ultrasonic energy between one or more transducers and a tissue region.

Ultrasound imaging of specular-reflecting target

A hand-held apparatus can be used to assist in guiding a probe or locating a particular anatomical target in a subject. The apparatus can include an ultrasonic transducer located on or within a housing and configured to generate ultrasonic energy directed into tissue of a subject and configured to receive a portion of the ultrasonic energy reflected by a target located within the tissue. In an example, the apparatus can include a motion tracking circuit configured to provide information indicative of a motion of the hand-held apparatus to the processor circuit, and a display configured to present information about a location of the target with respect to a portion of the hand-held apparatus, the information about the location determined by the processor circuit using the obtained information indicative of the ultrasonic energy reflected by the target and the information indicative of the motion of the hand-held apparatus.

Ultrasound for locating anatomy or probe guidance

Methods, systems, and computer readable media for monitored application of mechanical force to samples using acoustic energy and mechanical parameter value extraction using mechanical response models can be used for determining mechanical property parameters of a sample. An exemplary method includes applying acoustic energy to a sample to apply a mechanical force to the sample, measuring a response by the sample during the application of the acoustic energy, measuring a recovery response of the sample following cessation of the application of the acoustic energy, and determining a value for at least one additional mechanical property parameter of the sample based on the response measured during application of the acoustic energy and the recovery response measured following cessation of the application of acoustic energy.

Methods, systems, and computer readable media for monitored application of mechanical force to samples using acoustic energy and mechanical parameter value extraction using mechanical response models

Apparatus or techniques can include obtaining information indicative of energy, such as ultrasonic energy, reflected from a tissue region, forming respective input matrices representative of the obtained information, the input matrices respectively comprising an ensemble-of-interest and at least one ensemble corresponding to a spatial location nearby a spatial location corresponding to the ensemble-of-interest, performing respective singular value decompositions on the respective input matrices to obtain respective sets of singular values corresponding to respective sets of singular vectors, obtaining respective output matrices including weighting a respective projection of a respective ensemble-of-interest onto at least one of the singular vectors included in a respective set of singular vectors, and, using the respective output matrices, at least one of determining a characteristic, or constructing an image, of at least a portion of the tissue region.

Singular value filter for imaging or detection

Techniques (e.g., system, apparatus, method, machine-readable medium) can be configured for characterizing a rheological or other structural physical property of a sample of a substance. In an example, this can include acoustically bidirectionally deforming the portion of the sample over a deformation range about a neutral-deformation locus within the deformation range, measuring a deformation response of at least a portion of the sample to the insonification, and characterizing the physical property of the sample using the measured response of at least a portion of the sample to the insonification, even in the presence of a flowing substance.

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Charlottesville, VA, United States of America

F William Mauldin, Jr