Opertech Bio, Inc.

3-dimensional Pharmaceuticals, Inc.

Johnson & Johnson Pharmaceutical Research & Development, LLC

Redpoint Bio Corporation

Imiplex LLC

Other

International Flavors & Fragrances Inc.

F Raymond Salemme

R Kyle Palmer

Dimitris K Agrafiotis

Patricia C Weber

Victor S Lobanov

Joseph Kwasnoski

Mark Lawrence Dewis

Michael W Pantoliano

Robert Bryant

Barry A Springer

Eugenio C Petrella

Debra Merritt

Kenneth J Kraut

Roy Kyle Palmer

S Paul Lee

M N Tulu Buber

Rok Cerne

Francis Xavier Brennan

Daniel J Long

Dmitri N Rassokhin

Dennis Sprous

Peihong Zhou

Mark A Rould

Gillian Morgan

Described herein are various apparatus and systems useful in sensory discrimination. Through the use of a multi-well sample plate, the high-throughput analysis apparatus and method allow for rapid sensory discrimination of a large number of samples.

High-throughput operant sensory discrimination apparatus and method

A method of assembling a protein nanostructure on a surface including selectively patterning a surface with a fixation site, bringing a protein node into contact with the surface, and allowing the protein node to bond with the fixation site, so that the position and/or orientation of the protein node is constrained, and compositions.

Method of protein nanostructure fabrication

Engineered proteins are used in the assembly of two-dimensional and three-dimensional nanostructure assemblies, based on systematic design and production of protein node structures that can be interconnected, for example, with streptavidin or streptavidin-incorporating struts to produce structures with defined dimensions and geometry. Nanostructure assemblies having utility as functional devices or as resists for the patterning of substrates have architectures including polygons, polyhedra, two-dimensional lattices, and three-dimensional lattices.

Node polypeptides for nanostructure assembly

The present invention is directed to the use of one or more rebaudioside C polymorphs, or stereoisomers thereof, to enhance the sweet taste of a flavoring, such as glucosylated steviol glycoside, rebaudioside A, ammoniated glycyrrhizin, neohespherdin dihydrochalcone or thaumatin.

Methods for using rebaudioside C as a flavor enhancer

The present invention is directed to the use of rebaudioside C, or a stereoisomer thereof, for enhancing the sweet taste of carbohydrate sweeteners, such as sucrose and fructose. The present invention is also directed to consumables comprising a combination of a carbohydrate sweetener and rebaudioside C, or a stereoisomer thereof.

Rebaudioside C and its stereoisomers as natural product sweetness enhancers

The present invention is directed to methods of enhancing insulin release, GLP-1 release, and insulin sensitivity, methods of increasing insulin gene expression, methods of decreasing gastric secretion and emptying and glucagons secretion, and methods of inhibiting food intake, and methods of treating diabetes mellitus, insulin resistance syndrome, hyperglycemia, and obesity comprising administering to a subject an effective amount of a TRPM5 inhibitor.

Use of a TRPM5 inhibitor to regulate insulin and GLP-1 release

A method and computer product is presented for mapping n-dimensional input patterns into an m-dimensional space so as to preserve relationships that may exist in the n-dimensional space. A subset of the input patterns is chosen and mapped into the m-dimensional space using an iterative nonlinear mapping process. A set of locally defined neural networks is created, then trained in accordance with the mapping produced by the iterative process. Additional input patterns not in the subset are mapped into the m-dimensional space by using one of the local neural networks. In an alternative embodiment, the local neural networks are only used after training and use of a global neural network. The global neural network is trained in accordance with the mapping produced by the iterative process. Input patterns are initially projected into the m-dimensional space using the global neural network. Local neural networks are then used to refine the results of the global network.

System, method, and computer program product for representing object relationships in a multidimensional space

A microtiter plate system includes an integral heater. In an embodiment, the integral heater includes a heater plate. In another embodiment, the integral heater includes resistive heater wires positioned beneath and/or between the wells of a microtiter plate. In an embodiment, the microtiter plate system includes optically clear well bottoms that permit sensing and measurement of samples through the optically clear well bottoms. In an implementation, an optically clear heater is positioned beneath the optically clear well bottoms. In an alternative implementation, resistive heater wires are positioned between the wells. In an embodiment, the microtiter plate system includes a microtiter plate lid with an integral heater, which can be implemented using a heater plate, resistive wires, and the like. In an embodiment, the microtiter plate system includes an integral non-contact heater, such as a ferrous plate and/or ferrous particles, powder and/or fibers, which generate heat when subjected to an electromagnetic field. An electromagnetic field can be generated by an inductive coil or the like. In an embodiment, the microtiter plate system includes an integral non-contact heater which generates heat when subjected to microwave radiation from a microwave generator. In an embodiment, the microtiter plate system includes an integral thermostat that maintains a substantially constant temperature in the microtiter plate system.

Microtiter plate with integral heater

The present invention determines properties of combinatorial library products from features of library building blocks. At least one feature is determined for each building block of a combinatorial library having a plurality of products. A training subset of products is selected from the products, and at least one property is determined for each product of the training subset. A building block set is identified for each product of the training subset, and an input features vector is formed from the features of the identified building blocks for each product of the training subset. A supervised machine learning approach is used to infer a mapping function that transforms the input features vector for each product of the training subset to the corresponding at least one property for each product of the training subset. After the mapping function is inferred, it is used for determining properties of other products of the library from their corresponding input features vectors.

Method, system, and computer program product for determining properties of combinatorial library products from features of library building blocks

The present invention provides a method for ranking the affinity of each of a multiplicity of different molecules for a target molecule which is capable of unfolding due to a thermal change. The method comprises (a) contacting the target molecule with one molecule of a multiplicity of different molecules, in the presence of a 5-(4&Prime;-dimethylaminopheny-2-(4&prime;-phenyl)oxazole derivative dye, in each of a multiplicity of containers; (b) simultaneously heating the multiplicity of containers; (c) measuring the fluorescence in each of the containers; (d) generating thermal unfolding information for the target molecule as a function of temperature for each of the containers; (e) comparing the thermal unfolding information obtained for each of the containers to the thermal unfolding information for the target molecule in the absence of any of the molecules in the multiplicity of different molecules; and (f) ranking the affinities of each of the molecules according to the difference in the thermal unfolding information between the target molecule in each of the containers and the target molecule in the absence of any of the molecules in the multiplicity of different molecules.

Microplate thermal shift assay for ligand development using 5-(4&Prime;dimethylaminophenyl)-2-(4&prime;-phenyl)oxazole derivative fluorescent dyes

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Yardley, PA, United States of America

F Raymond Salemme