Philip Morris Inc.

Philip Morris USA Inc.

Chrysalis Technologies Incorporated

Crysalis Technologies Incorporated

Philip Morris Products S.a.

F Murphy Sprinkel, Jr

Walter Allen Nichols

D Bruce Losee

Francis V Utsch

Constance H Morgan

Mary Ellen Counts

Kenneth A Cox

A Clifton Lilly, Jr

Susan E Wrenn

Willie G Houck, Jr

Jerry F Whidby

William R Sweeney

Grier S Fleischhauer

Douglas D McRae

Jay A Fournier

Michael L Watkins

Billy J Keen, Jr

John R Hearn

Alfred L Collins

Ulysses Smith

James L Myracle

Constance H Nichols

Amitabh Das

Wynn R Raymond

Peter J Lipowicz

Seetharama C Deevi

Charles T Higgins

Sudarsan Srinivasan

Timothy Scott Sherwood

Everett C Grollimund

G Robert Scott

Donald L Brookman

Robert L Ripley

Robert E Lee

Gary E Grollimund

James M Washington

Bernard C LaRoy

Renzer R Ritt, Sr

Niranjan Maharajh

Hugh J McCafferty, Ii

David Ammann

Timothy Paul Beane

Sirisha P Reddy

Scott A Sowers

Edward S Gee

John M Campbell

Kenneth S Houghton

Zelita R Washington

Douglas Mcrae

Don Brookman

Sirisha Reddy

A drug delivery system, which includes an aerosol generator unit, a pumping unit, a flow tube, at least one condensate collector and an aerosol transition adapter. The aerosol generator forms an aerosol from a liquid formulation, which is partially volatilized. The pumping unit supplies the liquid formulation to the aerosol generator unit and a flow tube having an inlet end in fluid communication with an outlet of the aerosol generator unit and an outlet adapted for connection to a patient interface, which supplies ventilation gas to a patient's lungs. The system also includes at least one condensate collector adapted to collect condensed liquid or liquid produced by the aerosol generator unit, and a transition adapter arranged to mix aerosol produced by the aerosol generator unit with heated air or ventilation gas and direct the mixed aerosol into the inlet end of the flow passage.

Continuous high pressure delivery system

A disposable aerosol generator for use with an inhaler device which includes a heater adapted to volatilize fluid stored in the disposable aerosol generator and method of using the inhaler. The disposable body includes a sealed chamber and an outlet, the chamber being located between first and second layers of material. The chamber holds a predetermined volume of a fluid which is expelled through the outlet when the fluid in the chamber is volatilized by the heater. The disposable body can include a series of spaced apart aerosol generators, each of which can be advanced to a release position at which the heater can heat one of the fluid containing chambers. Prior to heating the fluid, the outlet can be formed by severing the first and/or second layer with a piercing element and the volatilized fluid can be expelled from the outlet into a passage of a dispensing member.

Disposable aerosol generator system and methods for administering the aerosol

A temperature and flow rate controlled capillary aerosol generator includes two heating zones optionally separated by a region in which a pressure drop is induced. Power is metered or applied to the downstream, second zone to achieve a target resistance, and therefore a target temperature, while power is metered or applied to the upstream, first zone to achieve a target mass flow rate exiting the second zone. A target temperature is achieved in the second zone to generate an aerosol from the liquid flowing through the generator at the desired mass flow rate.

Aerosol generator having temperature controlled heating zone and method of use thereof

A disposable aerosol generator for use with an inhaler device, which includes a heater adapted to volatilize liquid stored in the disposable aerosol generator and a method of using the inhaler, is provided. The disposable body includes a sealed chamber and an openable outlet. The chamber is located between first and second layers of material. The chamber holds liquid, which is expelled through the opened outlet when the fluid in the chamber is volatilized by the heater. The disposable body can include a series of spaced apart aerosol generators, each of which can be advanced to a release position at which the heater can heat one of the fluid containing chambers. Prior to heating the liquid, the outlet can be opened and the volatilized fluid can be expelled from the opened outlet into a passage of a dispensing member.

Disposable inhaler system

An aerosol generator includes a flow passage having an inlet and an outlet, a heater arranged relative to the flow passage for heating the flow passage, a source of material to be volatilized in communication with the inlet of the flow passage, a valve to open and close communication between the source of material and the inlet of the flow passage, and a pressurization arrangement for causing material in the source of material to be introduced into the flow passage when the valve is in an open position. The aerosol generator further includes a source of power for operating the heater and the valve, and a control device for controlling supply of power from the source of power to the heater and the valve. A metering device in an inhaler includes a pressurized source of medicated fluid and a metering chamber configured to deliver a predetermined volume of fluid to a heated flow passage in the inhaler. The metering chamber can be part of a rotary valve having a bore and a displacement member moveable within the bore from a first position where the fluid is loaded into the bore to a second position where the predetermined volume is ejected out of the bore. Another metering chamber has an elastic portion of a delivery passage in fluid communication with the pressurized source of liquid and the elastic portion of the delivery passage is deformed to eject the predetermined volume.

Aerosol generator and methods of making and using an aerosol generator

A cigarette includes an ignition element in contact with tobacco, surrounded by a composite outer wrapper. The outer wrapper is impervious to oxygen causing the tobacco to extinguish between puffs. The ignition element, however, has a longer static burn time than the tobacco and remains smoldering between puffs. Upon a subsequent puff, the smoldering ignition element re-ignites the tobacco. One or more initially-occluded perforations in the outer layer maintain the uniformity in combustion of the tobacco and ignition element.

Cigarette having reduced sidestream smoke

An aerosol generator includes a fluid supply which supplies fluid to a fluid passage and a heater which heats the fluid into a gaseous state, the fluid passage being located between opposed layers of a laminate. The fluid passage can be a capillary sized passage formed by locating a mandrel between opposed layers of the laminate, bonding the layers together and removing the mandrel such that the space previously occupied by the mandrel forms the fluid passage. The opposed layers of the laminate can be copper sheets and ceramic layers can be provided on the outside of the copper layers. The aerosol generator can be used to generate aerosols containing medicated materials.

Aerosol generator having heater arranged to vaporize fluid in fluid passage between bonded layers of laminate

A fluid vaporizing device includes two concentric, electrically conductive tubes, the tubes being electrically and physically connected near a distal end of the tubes, and the tubes each having electrical connections to the power source, with the electrical connections to a power source being near a proximal end of the tubes. The proximal end of an inner one of the tubes is in fluid communication with a source of fluid. The device can be used to aerosolize medicament containing solutions to produce an aerosol with particles within a desired size range.

Concentric controlled temperature profile fluid vaporizing device

An aerosol generator includes a fluid passage arranged between a first and a second layer wherein the first and second layers at least partially define the fluid passage. A liquid supply is arranged to provide a fluid in liquid phase to the fluid passage. The aerosol generator also includes a heater arranged to volatilize the fluid in the fluid passage. An outlet of the aerosol generator is arranged to receive the volatilized fluid and direct the volatilized fluid out of the fluid passage. The aerosol generator can be used to generate aerosols containing medicated materials.

Aerosol generator having heater in multilayered composite and method of use thereof

An aerosol generator includes a heater arrangement having multiple heating sections and corresponding flow paths for volatilization of a fluid in liquid form. The flow paths can include first and second flow paths which are parallel to each other and sized such that the first flow path is smaller than the second flow path. During delivery of liquid to the flow paths, a smaller amount of vaporized liquid can be ejected from the first flow path, and the bulk of the vaporized liquid can be ejected from the second flow path.

Aerosol generator having a multiple path heater arrangement and method of use thereof

Aerosol generator having multiple heating zones and methods of use thereof

Growing community of inventors

Glen Allen, VA, United States of America

F Murphy Sprinkel, Jr