Cook Biotech, Inc.

Cook Medical Technologies LLC

Cook Incorporated

Muffin Incorporated

F Joseph Obermiller

Umesh H Patel

Michael C Hiles

Clay D Fette

Steve Chen

Brian C Case

Jacob A Flagle

Matthew R Graham

Brian L Bates

Bhavin Shah

Chad E Johnson

David Nigel Armstrong

Mark W Bleyer

Thomas A Osborne

Ram H Paul, Jr

Sean Chambers

Cleon Stanley

Mark Duncan

Jeremy Metz

Neal E Fearnot

Steven Charlebois

Charles W Agnew

Dusan Pavcnik

Michael W Hardert

Michael L Garrison

James B Hunt

Michael D Deckard

Jeffrey A Miller

Kathryn Evert

David M J Ernst

Tyler Novak

P Arun Mohan

Ryan Dempsey

Christopher Nelson

Andrew J Kaucher

Derick C Miller

Brain L Bates

Kevin D Parish

David N Armstrong

Wade L Colburn

Christine M Bronikowski

Described are medical graft products, systems, and methods for treating fistulae. Certain products of the invention are configured to have portions residing in and around a primary fistula opening, e.g., one occurring in a wall of the alimentary canal. One such product includes a biocompatible graft body which is configured to block at least the primary opening. The graft body includes a capping member, which is configured to contact portions of the alimentary canal wall adjacent to the primary opening, and an elongate plug member extending from the capping member, which is configured to extend into at least a portion of the fistula. In certain embodiments, a graft body component has the capacity to expand or otherwise change form to provide a suitable capping arrangement. Such a component can include a resilient wire frame, e.g., one that is self-expandable or one that requires at least some manipulation in order to expand.

Fistula grafts and related methods and systems for treating fistulae

Described are devices, methods, and systems useful in the treatment of fistulae, and in certain embodiments those having openings extending into the alimentary canal, such as anorectal fistulae. Illustratively, an anorectal fistula can be treated by placing a volumetric construct within the primary opening of the fistula. In certain embodiments, the volumetric construct can include a rolled remodelable material processed to form a substantially unitary body. Advantageous such remodelable materials can include collagenous extracellular matrix materials, such as small intestine submucosa.

Volumetric grafts for treatment of fistulae and related methods and systems

Described are medical graft products, systems, and methods useful for treating fistulae, particularly enterocutaneous fistulae. Certain products of the invention are configured to have portions residing in and around a primary fistula opening in a wall of the alimentary canal. One such product includes a biocompatible graft body which is configured to block at least the primary opening. The graft body includes a capping member connected to an elongate plug member. The capping member is configured to contact portions of the alimentary canal wall adjacent to the primary opening, and the elongate plug member is configured to extend into at least a portion of the fistula. A graft product of this sort may be particularly adapted to allow a portion of the capping member to be positioned alongside an exterior, lateral surface of the plug member, e.g., when placed in a delivery device lumen. Such a capping member may be hingedly or non-hingedly coupled to the elongate plug member.

Fistula grafts and related methods and systems useful for treating gastrointestinal and other fistulae

Among other things, there are disclosed apparatuses and methods for medically sealing an opening in a vessel or wall. For example, in medical applications, a delivery tube is provided for insertion through a sheath into a vessel (e.g. a blood vessel). A dome-shaped seal fixed to a filament, an absorbent and/or compressible buffer, and a locking member are provided in the delivery tube. The delivery tube is configured so that it can be inserted into the vessel through a sheath. Tension is maintained on the filament to hold the seal against the tube or sheath. The sheath is pulled out, which pulls out the tube at the same time, leaving the seal over the opening in the vessel wall. The locking member compresses the buffer against the outside of the vessel and with the filament holds the seal in place against the inside of a vessel.

Devices and methods useful for sealing bodily openings

Described are stent graft devices and methods for their preparation and use. Expandable stent graft devices of the invention include inner and/or outer coverings uniquely applied and associated with surfaces of the stent. In certain described embodiments, bioremodelable materials such as ECM materials are vacuum pressed onto and/or around elements of a stent in the manufacture of a stent graft device.

Stent graft devices having collagen coating

Fistula grafts and related methods and systems useful for treating gastrointestinal fistulae

This invention relates in one aspect to the treatment of a vascular vessel with a biomaterial. The biomaterial can be a remodelable material that strengthens and/or supports the vessel walls. Additionally the biomaterial can include a variety of naturally occurring or added bioactive agents and/or viable cellular populations.

Methods for modifying vascular vessel walls

Described are medical products, systems, and methods for treating fistulae having a primary opening, such as in the alimentary canal. Certain methods of the invention include providing an implantable material including a compliant sheet form biocompatible material, and forcing this sheet form biocompatible material into the primary opening so as to deform the sheet form biocompatible material to conform to and block the primary opening. The biocompatible material preferably comprises a remodelable material, for example, a remodelable extracellular matrix material such as submucosa.

Fistula graft with deformable sheet-form material

Described are medical graft materials and devices which can be usefully modified with liquid additives such as cell suspensions, bioactive agents, or combinations of these. The medical graft materials and devices can have a first outer surface and a second outer surface and can define an internal chamber between the first outer surface and the second outer surface. The medical graft materials and devices can also have at least one region of the graft material interrupting the chamber and surrounded by the chamber. Also described are methods for making and using these medical graft materials and devices.

Modifiable medical grafts and related methods and apparatuses

Described are expanded collagenous materials and methods for their preparation and use. Certain expanded collagenous materials can be prepared by treating a first collagenous material with an alkaline substance under conditions effective to expand the first collagenous material, and recovering the expanded material. Expanded materials can exhibit beneficial persistence and tissue generation characteristics when implanted, and can be used in the formation of highly porous medical implant bodies which can be compressed to fractions of their original volume and will thereafter substantially recover their original volume.

Physically modified extracellular matrix materials and uses thereof

Described, in certain respects, are unique methods and systems for treating fistulae and other passageways and openings in the body. In some embodiments, treatment will be performed on fistulae that include a passage extending through a subcutaneous wall or wall-like structure. Illustratively, such a passage can extend through a subcutaneous tissue wall that includes, at a minimum, portions of an intestinal wall, and in this regard, such a wall can have a first side that is provided by the luminal side of the intestines and a second subcutaneous side that is provided, for example, by the abluminal side of the intestines and/or by other subcutaneous tissues adhered to this abluminal side. Some inventive products and methods involve sealing off the passage from both sides of the wall, for example, where a sealing element is placed on each side of the wall over an opening to the passage.

Methods and systems for treating complex fistulae

Described are medical products, systems, and methods useful for treating fistulae, particularly enterocutaneous fistulae. Certain inventive products are configured to have portions residing in and around a primary fistula opening in a wall of the alimentary canal. One product includes a graft body which is configured to block at least the primary opening. The graft body includes a capping member connected to an elongate plug member. The capping member is configured to contact portions of the alimentary canal wall adjacent to the primary opening, with the elongate plug member extending into at least a portion of the fistula. A product of this sort may be particularly adapted to allow a portion of the capping member to be positioned alongside an exterior, lateral surface of the plug member, e.g., when placed in a delivery device lumen. Such a capping member may be hingedly or non-hingedly coupled to the elongate plug member.

Growing community of inventors

West Lafayette, IN, United States of America

F Joseph Obermiller