Merck + Co., Inc.

F Edward Roberts

Thomas R Verhoeven

Kenneth M Ryan

Chris H Senanayake

Edward J Grabowski

David M Tschaen

Paul J Reider

David J Mathre

Michel M Chartrain

Thomas J Blacklock

Paul Sohar

Todd K Jones

Lyndon C Xavier

Brian Heimbuch

Neal C Connors

Randolph L Greasham

Roger C Olewinski, Jr

Barbara A Jackey

Francis P Gailliot

Christ H Senanayake

Chanyong Lee

Barry C Buckland

Victor J Grenda

Julie J Mohan

A process is disclosed that bioconverts indene to (1S)-amino-(2R)-indanol substantially free of any of its stereoisomers, by the action of a strain of P. putida or Rhodococcus sp., followed by various chemical step(s), e.g., chiral specific crystallization, treatment with strong acid in the presence of acetonitrile.

Conversion of indene to (1S)-amino-(2R)-indanol free of any

A regioselective processes are disclosed for the synthesis of (1R,1S)-amino-(2S,2R)-alkanol, particularly (1R,1S)-amino-(2S,2R)-indanol.

Regiospecific processes to make cis-1-amino-2-alkanol from diol

A regioselective process is disclosed for synthesis of 1R-amino-2S-indanol or 1S-amino-2R-indanol, wherein the stereochemical integrity of the carbon-oxygen bond at C-2 in the indene oxide starting material is retained.

Regiospecific process to make cis-1-amino-2-alkanol from epoxide

5,6-Dihydro-4-(R-amino)-4H-thieno[2,3-b]-thiopyran-2-sulfonamide-7,7-dioxid e is a potent carbonic anhydrase inhibitor useful in the treatment of ocular hypertension and glaucoma. The S-(+)-enantiomer of that compound, the more active enantiomer, is prepared by a process involving an intermediate step of an enantioselective reduction of a carbonyl group employing an oxazaborolidine chiral catalyst.

Enantiospecific synthesis of

A regeneratable polymer-supported Pd(O) catalytic deblocking process using a regeneratable polymer-supported Pd(O) catalyst in a biphasic system deblocks various allyl-protected ester, carbonates, carbamates and cinnamyl esters.

Deblocking process for allyl esters with regeneratable polymer supported

Organic sulfur compounds containing a carbon-sulfur double bond are used to remove homogeneous catalyst group VIII metals from chemical process streams.

Process for removal of homogeneous catalyst group VIII metals from

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Princeton, NJ, United States of America

F Edward Roberts