Iowa State University Research Foundation Inc

Department of Agriculture for and on Behalf of the State of New South Wales

F Chris Minion

Steven P Djordjevic

Tsungda Hsu

Gregory G Mahairas

Kevin L Knudtson

Laszlo Stipkovits

Sreekumar A Menon

Sergey Artiushin

polypeptides and nucleic acids, as well as nucleic acid expression vectors and host cells containing nucleic acid vectors are provided. In addition, compositions containingpolypeptides and nucleic acids are provided for use in methods of treating swine to prevent enzootic pneumonia. Furthermore, the invention provides diagnostic tests for the detecting ofinfection in swine herds.

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The invention features fusion agents such as fusion proteins that are useful for the treatment of and prevention from diseases that are susceptible to the effects of cellular (Th1 type) immune responses. Also encompassed by the invention are nucleic acids encoding the fusion proteins of the invention, vectors containing the nucleic acids, and cells containing the vectors. The invention includes methods of making and using the fusion agents of the invention.

Vaccine adjuvant

A Mycoplasma hyopneumoniae protein prepared by recombinant DNA or synthetic means, DNA sequences coding for the protein, an expression vector and transformed host containing the DNA sequences, a vaccine based on the protein, a vaccine based on the DNA sequences, methods of treating swine to prevent enzootic pneumonia using the vaccines, and diagnostic tests based on the protein or antibodies raised against it for detecting the presence of Mhyo infection in swine herds.

Recombinant mycoplasma hyopneumoniae vaccine

Mycoplasma expression system

Disclosed herein is a PCR-based assay for Mycoplasma hyopneumoniae, a species-specific primer pair for use in the assay, and a related diagnostic kit. The primer pair is made up of an oligonucleotide having the nucleotide sequence 5'-AAGTTCATTCGCGCTAGCCC-3' and an oligonucleotide having the nucleotide sequence 5'-GCTCCTACTCCATATTGCCC-3'. Preferably, the kit contains an oligonucleotide probe having the sequence 5'-GGTAGCCCTTCCTTTGAGGT-3'.

Growing community of inventors

Ames, IA, United States of America

F Chris Minion