Egis Gyogyszergyar Rt.

Richter Gedeon Nyrt.

Egis Gyogyszergyar Nyrt

Éva Schmidt

Gyula Simig

Judit Laszy

János Éles

József Barkóczy

György Lévay

Péter Kótay Nagy

István Gacsályi

Gábor Szénási

András Egyed

János Wellmann

Katalin Pallagi

László Gábor Hársing

Csilla Leveleki

Gyula Beke

László Hársing

Katalin Hornok

Hajnalka Kompagne

Béla Kiss

Anikó Miklósné Kovács

Gizella Bartáné Szalai

István Vágó

Bernadett Martonné Markó

Sándor Farkas

Ottília Balázs

György Levay

Judit Ráczné Bajnógel

Éva Bozó

Gäbor András Wágner

Norbert Antal Kirschner

Noémi Nagy

István Gyertyán

Péter Kotay Nagy

Anikó Miklosne Kovacs

Judit Raczne Bajnogel

József Barkoczy

István Gacsalyi

Katalin Sághy

Zsolt Komlódi

György Keserü

Éva Szentirmay

ÉVa ÁGainÉ Csongor

Gábor András WÁGNER

Mónika Vastag

The present invention relates to new histamine H(H) receptor subtype selective ligands of the general formula (I) and/or geometric isomers and/or stereoisomers and/or diastereomers and/or salts and/or hydrates and/or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds and the use of these compounds as medicaments for treatment and/or prevention of conditions which require modulation of Hreceptors. The invention also cover the combinations of a compound of the general formula (I) and an acetylcholinesterase inhibitor. 

H3 antagonists containing phenoxypiperidine core structure

The invention relates to new piperidinyl-alkylamino-pyridazinone derivatives of the general Formula (I) (wherein R is hydrogen or C-alkyl; one of X and Y stands for hydrogen and the other represents a group of the general Formula (II) Hal stands for halogen; and n is 1 or 2) and pharmaceutically acceptable acid addition salts thereof a process for the preparation thereof and pharmaceutical compositions comprising said compounds. The compounds of the general Formula I exhibit anxiolytic effect and are useful in the treatment of anxiety 

Piperidinyl-alkylamino-pyridazinone derivatives, a process for the preparation thereof and pharmaceutical compositions containing said compounds

The invention refers to novel 2H-pyridazine-3-one derivatives of the formula I, pharmaceutical compositions containing the same and a process for the preparation of the active ingredient. The novel compounds possess neuroleptic effect and can be used, primarily, for the treatment of schizophrenia. In formula I, R stands for a hydrogen atom or a C, alkyl group, X and Y represent, independently, a hydrogen atom, a halogen atom or a group of the formula II, with the proviso that one of X and Y means always a group of the formula II, and then the other one stands for a hydrogen atom or a halogen atom, wherein in formula II n has a value of 1 or 2. 

2h-pyridazine-3-one derivatives, pharmaceutical compositions containing the same and a process for the preparation of the active ingredient

The invention relates to substituted alkylaminopyridazinone derivatives of the general Formula (I), (wherein Ris hydrogen or alkyl having 1-4 carbon atoms; one of X and Y stands for hydrogen or halogen and the other represents a group of the general Formula (II), Ris hydrogen or alkyl having 1-4 carbon atoms; n is 1, 2 or 3; Rstands for hydrogen, alkyl having 1-4 carbon atoms or aryl-(Calkyl); Z stands for oxygen; or Rand Z together with the groups placed between them form a piperazine ring; and Rstands for hydrogen, halogen, trifluoromethyl or alkoxy having 1-4 carbon atoms) and pharmaceutically acceptable acid addition salts thereof. The invention compounds are useful in the treatment of anxiolytic conditions and cognitive disorders.

Substituted alkylaminopyridazinone derivatives, process for the preparation thereof and pharmaceutical composition containing the same

Growing community of inventors

Budapest, Hungary

Éva Schmidt