Yeda Research and Develpment & Co. Ltd

Eytan Gershonov

Matityahu Fridkin

Yoram Shechter

Itzhak Goldwasher

Disclosed are conjugates of a polypeptide or oligopeptide with a low molecular weight lipophilic compound, the peptide and lipophilic group being covalently linked to one another either directly or via a connecting element, with the exception of (a) conjugates in which the peptide component consists of hirudin or peptide structurally derived from hirudin or a peptide derivative with hirudin-like properties, and (b) conjugates whose peptide component has been hydrophobically modified during their biosynthesis.

Long-acting drugs and pharmaceutical compositions comprising them

Monohydroxamate vanadium complexes of the formula (1): R&mdash;CO&mdash;NHOH.X, wherein R is a residue selected from: (i) H N&mdash;CH(COY)&mdash;(CH ) &mdash;, wherein n is 1, 2 or 3, and Y is OH or NH ; (ii) H N&mdash;CH &mdash;S&mdash;CH &mdash;; and (iii) pyridyl, piperidyl or tetrahydroisoquinolinyl; and X is a vanadium compound selected from a vanadyl (VO ), metavanadate (VO &minus;)or vanadate (VO ) salt, are useful for inducing normoglycemia and/or reducing blood glucose levels in diabetic patients.

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Hod Hasharon, Israel

Eytan Gershonov