Baylor Research Institute

Centre National De La Recherche Scientifique

Institut National De La Sante Et De La Recherche Medicale

Washington University

Université´ D'aix-Marseille

Technion Research & Development Foundation Ltd

Eynav Klechevsky

Jacques F Banchereau

Gerard Zurawski

Sandra M Zurawski

SangKon Oh

Yoram Reiter

Anne-Laure Flamar

Galit Denkberg

Jean-Pierre Gorvel

Sangkon Oh

Gerald Zurawski

Anna Martirosyan

The present disclosure provides for methods and compositions for the modulation of CD5 in a subject. Also provided are methods of detecting and monitoring diseases, such as inflammatory and autoimmune diseases.

Detection of CD5 and methods and compositions for modulating CD5

The present invention includes isolated anti-Langerin vaccines, methods for making and using an isolated anti-Langerin antibody or binding fragment thereof and one or more antigenic peptides at the carboxy-terminus of the isolated anti-Langerin antibody, wherein when two or more antigenic peptides are present, the peptides are separated by the one or more linker peptides that comprise at least one glycosylation site. The present invention also includes isolated vectors for the expression of the anti-Langerin antigen delivery vectors and their manufactures and use.

Vaccines directed to langerhans cells

The present invention includes compositions and methods for increasing the effectiveness of antigen presentation using a DCIR-specific antibody or fragment thereof to which an antigen is attached that forms an antibody-antigen complex, wherein the antigen is processed and presented by a dendritic cell that has been contacted with the antibody-antigen complex.

Vaccines based on targeting antigen to DCIR expressed on antigen-presenting cells

Cyclic beta glucan compounds function as an immunoadjuvant when administered prior to, concommitantly with, or subsequent to the administration of one or more antigens to a subject. These adjuvant compounds may be effectively used as dendritic cell activating molecules.

Immunoadjuvant compounds and uses thereof

The present invention includes compositions and methods for designing, making and using modular recombinant antibodies or fragments thereof with one half of a cohesin-dockerin pair that permits the rapid assembly of multivariant antigen conjugates.

Multivariable antigens complexed with targeting humanized monoclonal antibody

Growing community of inventors

Haifa, Israel

Eynav Klechevsky