Charité – Universitätsmedizin Berlin

Charite - Universitaetsmedizin Berlin

Eyk Schellenberger

Ralf Hauptmann

Jörg Schnorr

Bernd Hamm

Jing Xie

Monika Ebert

Harald Kratz

Matthias Taupitz

Susanne Wagner

Akvile Haeckel

Joerg Schnorr

Akvile Häckel

Gesche Genter

Jorg Schnorr

The invention provides novel iron(III) complexes with formulae (1) and (2). Furthermore, corresponding ligands with formulae (L1) and (L2) for the production of iron(III) complexes are disclosed.

Iron(III) complexes having new contrast agent properties, for magnetic resonance imaging

A process is provided in which the resulting Fe-tCDTA contrast agent has a reduced osmolality. The process according to the invention comprises the following steps:

Method for preparing an Fe-tCDTA contrast agent and product obtainable by the method

The present invention relates to a phosphate adsorbent on the basis of maghemite or maghemite/magnetite comprising (i) an iron oxide core comprising a crystal structure of inverse spinel iron oxide, (ii) a coating selected from monomeric carbohydrates, in particular monosaccharides or disaccharides, alditols, or mixtures thereof, and/or (iii) a pharmaceutical excipient selected from polymeric carbohydrates, wherein the phosphate adsorbent has the form of nanoparticles with a particle size of the iron oxide core (i) of less than 20 nm. The present invention further relates to a method for the production of a phosphate adsorbent on the basis of maghemite or maghemite/magnetite, to pharmaceutical compositions comprising the phosphate adsorbent, and to medical uses thereof, especially for the prevention and/or treatment of hyperphosphatemia.

Nanoparticulate phosphate adsorbent on the basis of maghemite or maghemite/magnetite, production and uses thereof

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Berlin, Germany

Eyk Schellenberger