Gelesis LLC

Massachusetts Institute of Technology

The General Hospital Corporation

Genetics Institute, Inc.

Medlogic Global Corporation

Neurohealing Pharmaceuticals, Inc.

Madash LLC

Other

Nova Pharmaceutical Corporation

Cytyc Health Corporation

Infimed, Inc.

Gel Sciences, Inc.

Pharmedica Ltd.

Pelias Technologies, Inc.

Madasa LLC

Eyal S Ron

Yishai Zohar

Alessandro Sannino

Robert Samuel Langer

Barry Joseph Hand

Christian Demitri

William F Crowley, Jr

Cosimo Saponaro

Hassan Heshmati

Jeffrey Alan Hubbell

Edith Mathiowitz

Abraham J Domb

Stephen C Rowe

Marina Temchenko

Mark T Kieras

Eric J Roos

Matthew E Schiller

Marcelo Merello

Neal M Farber

Steven Giannos

Thomas J Turek

Rohit Kothari

Julian N Nikolchev

David T Hung

Smadar Cohen

Lev E Bromberg

Eric Elenko

Susan M Love

Lev Bromberg

Michael A Moskowitz

James K Liao

Luigi Ambrosio

Robert S Langer

Benjamin S Isaacs

Himakshi Patel

Tina Patel

Yoram Rubin

Dov Tamarkin

Rober S Langer, Jr

Andrea Staubli

Robert G Schaub

Mark Chasin

Laetitia Olivieri

Tom Turek

Richard A Kenley

Anne Staples

Michal Orkisz

Mary Nallin Omstead

Annette Bianchi

Linda Gont

William F Crowley

The present invention relates to methods of managing weight, and treating overweight or obesity and treating or preventing diabetes in a subject in need thereof. In one embodiment, the method comprises the steps of (a) orally administering to the subject from about 0.7 g to about 4 g of crosslinked carboxymethylcellulose; and (b) orally administering to the subject at least about 100 mL of water per gram of crosslinked carboxymethylcellulose. Steps (a) and (b) are conducted prior to or with at least one meal per day.

Methods for treating overweight or obesity

The present invention provides a method of producing a polymer hydrogel comprising the steps of: (1) preparing an aqueous solution of a water soluble polysaccharide derivative and a polycarboxylic acid; (2) optionally agitating the solution, for example, by stirring; (3) isolating a polysaccharide derivative/polycarboxylic acid composite from the solution; and (4) heating the polysaccharide derivative/polycarboxylic acid composite at a temperature of at least about 80&#xb0; C., thereby cross-linking the polysaccharide with the polycarboxylic acid. The invention also provides polymer hydrogels produced by the methods of the invention.

Method for producing hydrogels

The present invention provides crosslinked carboxymethylcellulose having high elastic modulus coupled with high absorbance capacity when swollen in simulated gastric fluid/water (1:8) and simulated intestinal fluids. The invention further provides methods of making the crosslinked carboxymethylcellulose, compositions comprising the crosslinked carboxymethylcellulose and methods of using the crosslinked carboxymethylcellulose, for example, for treating overweight or obesity or for enhancing glycemic control.

Method for producing hydrogels coupling high elastic modulus and absorbance

Methods of enabling or improving the ability of a hydrogel to swell in the stomach of an animal and/or increasing the amount of time said hydrogel remains swollen in the stomach are described herein. In one embodiment, a polymer is administered in combination with one or more pH modifying agents which raise and maintain the pH of the micro environment of the polymer and/or the stomach in order inducing swelling in the polymer. The polymer can be a homopolymer, a copolymer, or a polymer blend or composite. In one embodiment, the polymer is a superabsorbent polymer ('SAP'). The polymers can also be administered with one or more active agents, such as appetite suppressants. The pH modifying agent and/or the active agent can be administered simultaneously with the polymer in the same dosage form, simultaneously with the polymer in separate dosage forms, or sequentially. The compositions are formulated for oral administration. The formulation can include drugs for delivery to the stomach, such as antibiotics, or the hydrogel can be used as a filler, for example, for obesity control. The formulation an also be used to enhance gastric retention, for example, for controlled drug delivery. Methods of delivering a drug are also described herein, along with medicaments for carrying out the methods of the present invention.

Use of polymeric materials with other substances for improved performance

Provided are orally administrable thin film dosage forms adapted to adhere to a mucosal tissue of a patient, wherein said film comprises mixtures of polymers and insulin.

Oral dissolving films for insulin administration, for treating diabetes

The present invention provides a method of treating constipation and compositions useful in said method. The method comprises administering to a subject in need thereof an effective amount of a crosslinked carboxymethylcellulose having high elastic modulus coupled with high absorbance capacity when swollen in simulated gastric fluid/water (1:8) and simulated intestinal fluids.

Method for treating constipation

The invention provides methods and compositions comprising an anti-cholinergic agent for decreasing saliva production and treating sialorrhea.

Methods and compositions for decreasing saliva production

The invention relates to an drug delivery device and a method for delivering multiple drugs over a prolonged period of time. The drug delivery device has two or more unitary segments comprising a drug-permeable polymeric substance, wherein at least one of the segments further comprises a pharmaceutically active agent. The invention also relates to a method for the treatment of a benign ovarian secretory disorder in a female mammal, a method of contraception, and a method of relieving the symptoms associated with menopausal, perimenopausal and post-menopausal periods in a woman.

Methods and devices for the sustained release of multiple drugs

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Lexington, MA, United States of America

Eyal S Ron