Oncohost Ltd.

Eyal Jacob

Yuval Shaked

Ella Fremder

Michal Harel

Ben Yellin

Yehonatan Elon

Coren Lahav

Itamar Sela

Provided are blocking agents to IL-1α, IL-1β, or IL-1R activity for use in combination with radiotherapy for treating cancer patients in which radiotherapy treatment induces IL-1α, IL-1β or both in their circulation.

Cancer treatment by blocking host-induced IL-1 in combination with radiotherapy

Methods of selecting a therapeutic agent to treat a cancer in a subject comprising receiving a plurality of protein data element values representing levels of the proteins in a biological sample from the subject, classifying each protein as a member of a process class, for each process class calculating a process score that represents the prominence of the process class to cancer treatment resistance and selecting at least one therapeutic agent that targets a selected process based on the process score. Systems for selecting a therapeutic agent are also provided.

Cancer process evaluation

Provided are blocking agents to IL-1&#x3b1;, IL-1&#x3b2;, or IL-1R activity for use in combination with radiotherapy for treating cancer patients in which radiotherapy treatment induces IL-1&#x3b1;, IL-1&#x3b2; or both in their circulation.

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Haifa, Israel

Eyal Jacob