Johnson Matthey Public Limited Company

Macfarlan Smith Limited

Ewart Grant

Saroop Matharu

Brian Heinrich

Nicolas Archer

Hongzhi Zhang

Maureen Young

Michael Bease

Barbara Jamieson

Amy Price

Timothy Davies

Saroop Singh Matharu

Brian W Heinrich

Improved processes for making opioid products having low impurity levels including making 14-hydroxycodeinone and 14-hydroxymorphinone from thebaine and oripavine, respectively.

Processes for making opioids including 14-hydroxycodeinone and 14-hydroxymorphinone

Improved processes for making hydrocodone and hydromorphone as well as their 8,14-dihydrothebaine and 8,14-dihydrooripavine derivatives and salts are disclosed.

Processes for making hydrocodone, hydromorphone and their derivatives

The present invention provides a process for preparing an oxymorphone acid adduct, said process comprising hydrogenating an aqueous solution of 14-hydroxymorphinone and an acid to form a solution of the oxymorphone acid adduct, wherein the hydrogenation is carried out at one or more temperatures greater than 40&#xb0; C. in the presence of a hydrogenation catalyst and hydrogen gas, wherein the level of 6&#x3b1;-oxymorphol produced is &#x2266;3.00 area % as determined by HPLC.

Process for the preparation of oxymorphone alkaloid and oxymorphone salts

The present invention provides a process for preparing an oxycodone acid adduct, said process comprising hydrogenating an aqueous solution of 14-hydroxycodeinone and an acid to form a solution of the oxycodone acid adduct, wherein the hydrogenation is carried out at one or more temperatures greater than ambient temperature in the presence of a hydrogenation catalyst and hydrogen gas, wherein the solution of oxycodone acid adduct comprises 6&#x3b1;-oxycodol in an amount &#x2266;about 0.800 area % as determined by HPLC.

Process

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Devens, MA, United States of America

Ewart Grant