Syngenta Corporation

Zeneca Limited

Ewan Campbell Boyd

Alan John Whitton

Jack Hugh Vass

Raymond Vincent Jones

Michael Charles Standen

David John Ritchie

Peter Karl Wehrenberg

Gillan Beveridge

David Alan Glanville

Gillian Beveridge

Timothy John Doyle

Jack Hugh Vaas

Jack Vass

The present invention relates, inter alia, to a process for preparing a compound of formula (I): using, as a catalyst 1,4-diazabicyclo[2.2.2]octane. 

Preparation of azoxystrobin

The present invention relates, inter alia, to a process for preparing a compound of formula (I): using a quinuclidine-based catalyst or an optionally 3-substituted N-methyl pryrrolidine-based catalyst. 

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The present invention relates, inter alia, to a process for preparing a compound of formula (I): which comprises either (a) reacting a compound of formula (II): with 2-cyanophenyl, or a salt thereof, in the presence of between 0.1 and 2 mol % of 1,4-diazabicyclo[2.2.2]octane, or (b) reacting a compound of the formula (III): with a compound of the formula (IV): in the presence of between 0.1 and 2 mol % of 1,4-diazabicyclo[2.2.2]octane; where W is the methyl (E)-2-(3-methoxy)acrylate group C(COCH)&#x2550;CHOCHor the methyl 2-(3,3-dimethoxy)propanoate group C(COCH)CH(OCH), or a mixture of the two groups. In addition, the present invention relates to a novel precursors of the compound of formula (I) and methods for making them. 

Processes for the preparation of azoxystrobin using dabco as a catalyst and novel intermediates used in the processes

4,6-Dichloropyrimidine is prepared by treating 4,6-dihydroxypyrimidine with a chlorinating agent of the formula R.sup.1 R.sup.2 R.sup.3 PCl.sub.2 wherein R.sup.1, R.sup.2 and R.sup.3 are independently alkyl or aryl, or one or more of the groups R.sup.1, R.sup.2 and R.sup.3 is linked to a polymer support. Conveniently, the chlorinating agent may be prepared in situ by reacting the corresponding phosphine oxide with phosgene. Thus, in a preferred process, 4,6-dichloropyrimidine is prepared by treating 4,6-dihydroxypyrimidine with phosgene in the presence of a phosphine oxide.

Chemical process

Process for preparing 4,6-dichloro-pyrimidine

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Grangemouth, United Kingdom

Ewan Campbell Boyd