Leybold Aktiengesellschaft

Sonosep Biotech Inc.

Leybold-heraeus Gmbh

Ewald Benes

Gernot Thorn

Martin Groschl

Friedrich-Werner Thomas

Felix Trampler

Wolfgang Burger

Franz Viehbock

Hans-Joachim Siegmund

Herbert Stori

Michael Schmid

Paul Berlinger

Particulate material suspended in a fluid is separated and recycled by means of an ultrasonic resonance wave. In a preferred embodiment, the ultrasonic resonance field is generated within a multilayered composite resonator system including a transducer, the suspension and a mirror parallel to each other. Dimensions and frequencies resonant to the whole system but not exciting Eigen-frequencies of transducer and mirror itself are chosen so that thermal dissipation is minimized. Generally, the process is suitable for all kinds of particles (solid, liquid or gaseous disperse phases) especially for hydrosols (particles in water) and for separation of biological particles such as mammalian, bacterial and plant cells or aggregates. Specialized applications in biotechnology are described including an acoustic filter for mammalian cell bioreactors or the selective retention of viable cells relative to nonviable cells.

Multilayered piezoelectric resonator for the separation of suspended

Particulate material suspended in a fluid is separated and recycled by means of an ultrasonic resonance wave. In a preferred embodiment, the ultrasonic resonance field is generated within a multilayered composite resonator system including a transducer, the suspension and a mirror parallel to each other. Dimensions and frequencies resonant to the whole system but not exciting Eigen-frequencies of transducer and mirror itself are chosen so that thermal dissipation is minimized. Generally, the process is suitable for all kinds of particles (solid, liquid or gaseous disperse phases) especially for hydrosols (particles in water) and for separation of biological particles such as mammalian, bacterial and plant cells or aggregates. Specialized applications in biotechnology are described including an acoustic filter for mammalian cell bioreactors or the selective retention of viable cells relative to non-viable cells.

The invention relates to a device for recognizing the impact site (29, 37) of a charge carrier beam on a target. This device has two position-sensitive detectors (22, 23) above the target which have a given distance from each other and from the target and on which via imaging systems (24, 25) the impact site (29, 37) of the charge carrier beam is imaged by means of X-rays. The output signals of these detectors (22, 23) are placed on a special evaluation device which determines all three spatial coordinates of the impact site (29, 37) of the charge carrier beam.

Device for recognizing the impact site of a charge carrier beam on a

The invention concerns apparatus for detecting the position of incidence (2) of a beam (1) of charge carriers on a target (3) wherein X-rays (4) starting from the position of incidence (2) are detected by detector (7) connected to an analyzing circuit (9) An imaging system (5, 50; 10, 11, 12) is provided which can cover all the positions (P.sub.1 . . . P.sub.8) that the positions of incidence (2) can take up and projects them on the sensing surface of a position-sensitive detector (7), wherein the projected coordinates (x', y') are directly proportional to the coordinates (x, y) of the position of incidence (2). In addition, a filter (6) highly transparent to the X-ray radiation range emitted from the position of incidence (2) is arranged between the target surface (3) and the position-sensitive sensor (7). The position-sensitive detector (7) emits electric signals which depend from the coordinates (x, y) of the position of incidence (FIG. 1).

Apparatus for detecting the position of incidence of a beam of charge

The invention relates to a system for determining the current thickness of changing coatings of a material on a substrate, using an electrically excitable, mechanically vibratable element (2) having at least one pronounced resonant frequency, which is excited to a steady vibration by an oscillator circuit (1) at a resonant frequency, and which is covered by the material in the same manner as the substrate. A signal (U.sub.D) is produced which depends on the damping caused by the coating of the vibratable element (2). This signal (U.sub.D) is compared with a known critical value signal (U.sub.DE) whereby it is possible to indicate when the vibratable element (2), which can be coated with the material only to a certain degree, must be replaced with a new vibratable element (FIG. 2).

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Biedermannsdorf, Austria

Ewald Benes