The University of Manchester

Technicka Univerzita V Liberci

Technologias Avanzadas Inspiralia S.l.

Institutut De Chimie Macromoleculara Petru Poni

Ustav Experimentatni Mediciny Akademie Ved Ceske Republiky Verejna Vyzkumna Instituce

Egu—hv Laboratory A.s.

Institutul De Chimie Macromoleculara Petru Poni

Ustav Experimentalni Mediciny Akademie Vedceske Republiky, V.v.i

Tecnologias Avanzadas Inspiralia S.l.

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David Lukas

Jaroslav Beran

Jan Valtera

Pavel Pokorny

Martin Bilek

Petr Mikes

Eva Kostakova

Jiri Chvojka

Constentin Ciobanu

Guillaume Saint-Pierre

Matej Buzgo

Aline Fiona Miller

Andrea Mickova

Miguel Herrero Gomez

Sandra Martinez Crespiera

Lubomir Kocis

Alberto Saiani

Catherine Merry

Kate Meade

Jean-Baptiste Guilbaud

Lucie Vyslouzilová

Jirí Chvojka

David Lukás

Richard Lukás

Pavel Pokorný

Petr Louda

Bozena Hégrová

A biocompatible and biodegradable medical device patch actuating primarily as soft tissue structural reinforcement. The device has a layered architecture, where the primary serves as suturing layer and mechanical support to a thick porous scaffold which can be coated with a mimic-like extra cellular matrix (ECM). The device can be provided to the end user under the format of independent layers that can be cut and assembled to the specific need to the end user and patient. The layers are assembled without the need of any adhesive. Totally haemocompatible and of behavior superior to polytetrafluoroethylene used for any soft tissue repaired, the field of this invention is demonstrated for cardiovascular therapy but should not be limited to it. It is of practical relevance of vein, tendon and hernias and dermal treatments.

Scaffold for cardiac patch

The invention relates to a method for production of polymeric nanofibers, in which polymeric nanofibers are created due to the action of force of an electric field on solution or melt of a polymer, which is located on the surface of a spinning electrode, whereby the electric field for electrostatic spinning is created alternately between the spinning electrode (), to which is supplied alternating voltage, and ions () of air and/or gas generated and/or supplied to proximity of the spinning electrode (), whereby according to the phase of the alternating voltage on the spinning electrode () polymeric nanofibers with an electric charge of opposite polarity and/or with segments with an electric charge of opposite polarity are created, which after their creation cluster together under the influence of the electrostatic forces into linear formation in the form of a tow or a band, which moves freely in space in direction of gradient of the electric fields away from the spinning electrode (). The invention further relates to a linear formation from polymeric nanofibers fabricated by this method.

Method for production of polymeric nanofibers by spinning of solution or melt of polymer in electric field

Growing community of inventors

Prague, Czechia

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