Evonik Operations Gmbh

Universiteit Gent

Evy Goossens

Richard Ducatelle

Filip Van Immerseel

Stefan Pelzer

Monika Flügel

Sarah Hark

Frank Thiemann

Florian Böhl

Bart Devreese

Venessa Eeckhaut

Lynn Vanhaecke

Fien De Meyer

Lieven Van Meulebroek

Griet Debyser

Growth performance, health and welfare of domesticated birds such as broilers heavily depends on a well-functioning intestinal tract. Consequently, there is a high need to find biomarkers that are specific for gut damage and that are easily applicable in the field. The present disclosure describes a set of 20 specific proteins that can be quantified in fresh fecal droppings and/or intestinal content of the birds and that each specifically correlate with a damaged gut.

Intestinal and fecal biomarkers for intestinal health of poultry

The invention pertains to an in vitro method for detecting avian intestinal dysbiosis, the method comprising determining the presence and/or level of isoleucyl-arginine (CHON) or isomers thereof in avian sample material wherein the presence and/or an increased level of isoleucyl-arginine (CHON) or isomers thereof in comparison to a non-affected control is indicative for avian intestinal dysbiosis.

In vitro method for detecting avian intestinal dysbiosis

The present invention pertains to an in vitro method for detecting intestinal barrier failure in an avian population, the method comprising the following steps: a) collecting a pooled fecal sample deriving from an avian population and b) determining the amount of at least one protein marker contained in said sample; wherein the at least one protein marker comprises or consists of an acute phase protein or a functional fragment thereof, and wherein an increased amount of said at least one protein marker contained in said sample versus a reference sample indicates intestinal barrier failure.

In vitro method for detecting intestinal barrier failure in animals

The present invention relates to a method for detectinginduced diseases in animals, the method comprising: a) collecting sample material of a specific animal or of a specific group of animals at consecutive points in time; b) determining the amount of a first marker and a second marker contained in the sample material; and c) determining the ratio of the first marker to the second marker contained in the sample material; wherein the first marker comprises a polynucleotide sequence being specific for thesub-species inducing the targeted disease; and the second marker comprises a polynucleotide being specific for the species; and wherein an increase in the ratio of the first marker to the second marker in the analyzed sample material over time is an indication of the targeted disease.

Method for detectinginduced diseases in animals

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Wachtebeke, Belgium

Evy Goossens