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Vsesojuzny Kardiologichesky Nauchny Tsentr Akademii Meditsinskikh Nauk

Institut Kardiologii Imeni A.l. Myasnikova Akademii Meditsinskikh Nauk

Vsesojuzny Kardiologichesky Nauchny Tsentr

Evgeny I Chazov

Vladimir N Smirnov

Vladimir P Torchilin

Zhanna D Bespalova

Valentin A Vinogradov

Mikhail I Titov

Boris L Pekelis

Alexandr V Maximenko

Anatoly B Davydov

Rustam I Utyamyshev

Gennady L Khromov

Vladimir I Metelitsa

Eduard A Babaian

Vladimir M Polonsky

Moisei A Lokshin

Vitaly A Burynin

Grigory M Grinberg

Alexandr K Giorgadze

Vladimir A Penin

Alexandr A Dzhikia

Sergei I Emelyanov

Gennady P Samokhin

Viktor S Goldmakher

Karel Martinek

Boris V Moskvichev

Igor M Tereshin

Gersh I Kleiner

Mikhail Y Ruda

Agris Z Skuya

Nikolai K Permyakov

Alexandr A Mishin

Tamara P Ostrovskaya

Ilia V Berezin

Elena G Tischenko

Valentina A Tischenko

Alexandr M Klibanov

Galina P Titova

Hexapeptide

Urokinase derivatives covalently bound to fibrinogen

A pharmaceutical preparation for the treatment of diabetes mellitus comprising the following components, in percent by weight:

Pharmaceutical composition for the treatment of diabetes mellitus

A method of preparing a polysaccharide derivative of fibrinolysin which comprises reacting fibrinolysin with dextran dialdehyde having a molecular mass of from 20,000 to 110,000 at a pH of from 8.0 to 9.5 and at a temperature within the range of from 5.degree. to 30.degree. C. with the formation of a covalent bond; the resulting fibrinolysin derivative is reduced with sodium borohydride and isolated.

Dextran derivative of fibrinolysin

A heat-resistant water soluble derivative of urokinase is prepared which comprises urokinase covalently bonded to a copolymer of acrylamide and acrylic acid having a molecular weight of 10,000 to 200,000 and a content of acrylic acid of 1% to 2%. The derivative contains 15% to 35% urokinase and has an esterase and amidolytic activity of from 10% to 80%.

Heat-resistant water soluble urokinase derivative

A method for producing a visible image of an object is disclosed in which a fermental plate is illuminated with ultrasonic waves and a latent image of the object is therefore produced therein which is developed using a solution of chromogenic substrates, comprising, for example, hydrogen peroxide and a water-soluble aromatic amine. An apparatus to practice the disclosed method comprises an ultrasonic generator to generate ultrasonic waves illuminating the object, a fermental plate to receive and convert the ultrasonic waves passed through the object to a visible image, and a tray filled with a developer to develop the latent image of the object in the fermental plate.

Method and apparatus for producing visible image of object

The extracorporeal circulation apparatus in accordance with the invention comprises a plurality of pneumatic diaphragm pumps incorporated in parallel relationship in a single fluid-flow system of extracorporeal blood perfusion. The electronic control system of the arrangement which processes the EKG signals is provided with a control signal distributor for sequential pump actuation such that the priming time of each pump is prolonged, frothing and haemolysis of the blood is prevented, and the stroke volume of the apparatus is maintained at a predetermined level.

Extracorporeal circulation apparatus

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Moscow, Russia

Evgeny I Chazov