Leland Stanford Junior University

Evgenios Neofytou

Geoffrey C Gurtner

Jayakumar Rajadas

Michael Gabriel Galvez

Richard Neil Zare

Tatsiana Lobovkina

Gunilla B Jacobson

Ramin E Beygui

Marie Russo

Compositions and methods are provided for the prevention and treatment of chronic wounds, including, without limitation, pressure ulcers and diabetic ulcers, by transdermal delivery of an agent that increases activity of HIF-1&#x3b1; in the wound.

Topical and transdermal delivery of HIF-1 modulators to prevent and treat chronic wounds

In accordance with the purpose(s) of the present disclosure, as embodied and broadly described herein, embodiments of the present disclosure, in one aspect, relate to nanoparticles, compositions including nanoparticles, methods of making nanoparticles, and the like. In particular, embodiments of the present disclosure include nanoparticles and compositions for the sustained release (e.g., release at a predetermined rate to maintain a certain concentration for a certain period of time) of an agent, such as a small interfering RNA (siRNA) from the nanoparticle.

Nanoparticles, nanoparticle delivery methods, and systems of delivery

Growing community of inventors

Stanford, CA, United States of America

Evgenios Neofytou