S.a. Fbfc International

Orthovita, Inc.

Fbfc International S.a.

Evert Schepers

Paul Ducheyne

Raymond Kempenners

Louis Van Hove

Marcel DeClercq, Deceased

Marcel De Clercq, Deceased

Raymond Kempeneers

D Scott Metsger

Methods for forming osseous tissue in defects in sites in the appendicular skeleton or sites exhibiting reduced metabolic state using bioactive glass granules containing 40 to 58% SiO.sub.2, 10 to 30% NaO, 10 to 30% CaO, and 0 to 10% P.sub.2 O.sub.5, and in the size range of from 200 to 300 micrometers, are described.

Bioactive granules for bone tissue formation

A sintered, shaped long-life dental implant or osseous prosthesis adapted for implantation into a human or animal body with chemical bonding to bone tissue. The implant or prosthesis is the result of sintering of a shaped mass of bioglass particles at or above a temperature softening the bioglass particles to form a bioreactive material having a composition comprising, by weight, 5-14% Na.sub.2 O, 0-12% P.sub.2 O.sub.5, 49-57% SiO.sub.2, and balance, no more than 33% CaO+CaF.sub.2, with the bioreactive material containing 0.5-7% CaF.sub.2. The implant or prosthesis has limited reactivity with bone tissue and a coefficient of expansion less than 10.sup.-5 K.sup.-1 from 0.degree. to 100.degree. C.

Bioreactive material for a prosthesis or composite implants

Process for the restoration of an osseous defect or deficiency by filling with osseous tissue with the aid of a bioreactive granular material causing an osteostimulation, the particles of said granular material being disintegrated from the inside, dissolved and replaced by osseous tissue, the granular material containing 40 to 55% SiO.sub.2, 10 to 32% Na.sub.2 O, 0 to 12% P.sub.2 O.sub.5 and 10 to 32% CaO, which has a grain size distribution between 280 and 425 .mu.m, sharp edges, an irregular profile and surface microdefects or microcracks.

Process for restoring an osseous defect or deficiency by filling with

A method is disclosed for preparing an improved bioreactive material of the glass or partially crystallized glass type for bone prostheses or dental implants, which can be welded to bone tissue by chemical bonding. The material consisting essentially of, by weight, 5 to 14% Na.sub.2 O, 0 to 12% P.sub.2 O.sub.5, 49 to 57% SiO.sub.2, and balance, no more than 33% CaO+CaF.sub.2, the material containing 0.5 to 7% CaF.sub.2, and is prepared by a method comprising the steps of preparing a mixture of powders constituting a precursor of the material made of carbonates, phosphates, silica, oxides and fluorides, melting, homogenizing, casting and cooling the mixture to obtain an intermediate, non-crystallized glass, optionally annealing, and then grinding, either pressing the non-crystallized ground glass obtained cold to shape it, then sintering naturally or under a load after degassing, or sintering under a load directly after degassing, then cooling and optionally polishing or machining.

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Leuven, Belgium

Evert Schepers