University of Iowa Research Foundation

University of Rochester

Ithaca College

Other

East Carolina University

Everett P Greenberg

James Philip Pearson

Barbara H Iglewski

Kenneth D Tucker

Kendall M Gray

Luciano Passador

Anatol Eberhard

Michael J Welsh

Andrew S Kende

Pradeep K Singh

Everett C Pesci

Sue M Travis

Jared B J Milbank

Jeffrey J Smith

The invention presented herein provides methods and compositions for the prevention and treatment of bacterial infections. The methods are based on the discovery that depletion of bioavailable iron stimulates surface motility in bacteria thus inhibiting the ability of a bacterial population to develop into a biofilm.

Methods of inhibiting and treating bacterial biofilms by metal chelators

Novel bacterial quinolone signal molecules and, more particularly,quinolone signal ('PQS') molecules, e.g., 2-heptyl-3-hydroxy-4-quinolone, and analogs and derivatives thereof are described. Therapeutic compositions containing the molecules, and therapeutic methods, methods of for regulating gene expression, methods for identifying modulators of the autoinducer molecules, and methods of modulating quorum sensing signaling in bacteria using the compounds of the invention are also described.

Autoinducer molecules and uses therefor

Autoinducer molecules, e.g., N-(3-oxododecanoyl)homoserine lactone, forare described. The molecules regulate gene expression in the bacterium. Therapeutic compositions and therapeutic methods involving analogs and/or inhibitors of the autoinducer molecules also are described. The molecules are useful for treating or preventing infection by

Autoinducer molecule

Autoinducer molecules, e.g., N-(3-oxododecanoyl)homoserine lactone, for Pseudomonas aeruginosa are described. The molecules regulate gene expression in the bacterium. Therapeutic compositions and therapeutic methods involving analogs and/or inhibitors of the autoinducer molecules also are described. The molecules are useful for treating or preventing infection by Pseudomonas aeruginosa.

A bactericidal factor isolated from the surface fluid of airway epithelial cells and uses therefore is described. The bactericidal factor is characterized as having the following features: a) a molecular weight of less than 10 kd; b) heat stable; c) broad spectrum activity including gram positive and gram negative bacteria, fungi, and methicillin resistant Staphylococcus; and d) decreased antimicrobial activity in increasing salt concentration.

Bactericidal factor in human airway surface fluid and uses thereof

Growing community of inventors

Iowa City, IA, United States of America

Everett P Greenberg