East Carolina University

The General Hospital Corporation

University of Rochester

University of Iowa Research Foundation

Memorial Sloan Kettering Cancer Center

Everett C Pesci

Andrew S Kende

Derek Shieh Tan

James Philip Pearson

Laurence G Rahme

Barbara H Iglewski

Everett P Greenberg

Cheng Ji

Indrajeet Sharma

James P Coleman

Jared B J Milbank

Debarshi Pratihar

Provided herein are compounds of Formula (I) and pharmaceuticals acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, and prodrugs thereof. Also provided are pharmaceutical compositions, kits, and methods involving the inventive compounds for the treatment and/or of an infectious disease (e.g., bacterial infection (e.g.,infection). 

Anthranilyl-adenosinemonosulfamate analogs and uses thereof

Novel bacterial quinolone signal molecules and, more particularly,quinolone signal ('PQS') molecules, e.g., 2-heptyl-3-hydroxy-4-quinolone, and analogs and derivatives thereof are described. Therapeutic compositions containing the molecules, and therapeutic methods, methods of for regulating gene expression, methods for identifying modulators of the autoinducer molecules, and methods of modulating quorum sensing signaling in bacteria using the compounds of the invention are also described.

Autoinducer molecules and uses therefor

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Greenville, NC, United States of America

Everett C Pesci