Warner-lambert Company

Pfizer Science and Technology Ireland Limited

Evelyn Madigan

William Tully

John O'Connell

A factory scale process for producing crystalline atorvastatin calcium includes the step of drying the isolated product in a vacuum pan dryer. The vacuum pan dryer has an agitator which is continuously rotated at a speed of approximately 1 rpm. High quality material is routinely and consistently produced with reduced cycle time.

Process for producing crystalline atorvastatin calcium

A unit for producing pyrogen controlled water on a small to medium factory scale comprises a number of charged ultrafiltration units arranged in parallel. Orifice plates are used to restrict and control the flow of deionized water to each filter . The filter units are mounted on a frame with a wheeled chassis which may be pushed or moved by a forklift truck to a site where pyrogen controlled water is required. The unit has an inlet line for connection to a supply of deionized water and an outlet line for connection to a user of pyrogen controlled water. The unit may be purged with nitrogen from a supply . Sampling ports in a common supply inlet and a common outlet ensure that the filtration efficiency can be closely monitored. The flow of water is monitored by a flowmeter and pressure sensors upstream of each filter facilitate a high level of control.

Growing community of inventors

Carrigaline, Ireland

Evelyn Madigan