US Government as Represented by the Secretary of the Army

USA as Represented by Secretary of the Navy

Johns Hopkins University

Glaxosmithkline Biologicals Sa

The Walter Reed Army Institute of Research

Kincaid, Randall L.

Evelina Angov

Jeffrey A Lyon

Joe D Cohen

Elke Bergmann-Leitner

Christian Asare Darko

Christian F Ockenhouse

David E Lanar

Randall L Kincaid

Arnoldo Barbosa

William Rogers

Sanjai Kumar

Collette J Hillier

Nirbhay Kumar

Rafael D Camerini-Otero

George C Tsokos

Gerald Voss

Jeffery A Lyon

William c/o Dept Of State Rogers

A synthetic nucleotide, which transcribes as the cell-traversal protein for ookinetes and sporozoites (CelTOS) antigen of Malaria, and methods of use thereof.

Recombinantly expressed plasmodium CelTOS antigen and methods of use thereof

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The present invention features immunogenic compositions based on pre-fertilization or post-fertilization antigens expressed in the circulating gametocytes in the peripheral blood of infected persons or on the malaria parastes' stages of development in the mosquito midgut including extracellular male and female gametes, fertilized zygote and ookinete. The invention also features methods to prevent the transmission of malaria using the immunogenic compositions of the invention.

Malaria vaccine

The invention is an DNA vaccine and method of use thereof for modulating the immune response against the circumsporozoite protein (CSP) of malaria parasites, using the CR2 binding motifs of C3d, especially p28.

CR-2 binding peptide P28 as molecular adjuvant for DNA vaccines

In this application is the expression and purification of a recombinant(3D7) MSP-1. The method of the present invention produces a highly purified protein which retains folding and disulfide bridging of the native molecule. The recombinant MSP-1is useful as a diagnostic reagent, for use in antibody production, and as a vaccine.

In this application is described the expression and purification of a recombinant(3D7) LSA-NRC polypeptide. The method of the present invention produces a highly purified polypeptide which is useful as a vaccine and as a diagnostic reagent.

Expression, purification and uses of a plasmodium falciparum liver stage antigen 1 polypeptide

In this application is described the expression and purification of a recombinant(FVO) MSP-1. The method of the present invention produces a highly purified protein that retains folding and disulfide bridging of the native molecule. The recombinant MSP-1is useful as a diagnostic reagent, for use in antibody production, and as a vaccine.

This application is the expression and purification of a recombinant(3D7) MSP-1. The method of the present invention produces a highly purified protein which retains folding and disulfide bridging of the native molecule. The recombinant MSP-1is useful as a diagnostic reagent, for use in antibody production, and as a vaccine.

Isolation and purification of P. falciparum merozoite protein-142 vaccine

The present invention includes the isolation of an oligonucleotide encoding Thermus aquaticus recA protein, and to the purified protein. The invention also includes methods of use of the protein, particularly, methods for hybridizing a primer to a complementary template with increased binding affinity at a temperature above 45.degree. C.

Growing community of inventors

Bethesda, MD, United States of America

Evelina Angov