Stichting Imec Nederland

Imec Nederland

Evelien Hermeling

Vojkan Mihajlovic

Carlos Agell

Fabian Beutel

Eva Wentink

A method for estimating a measure of cardiovascular health of a subject () comprises: receiving () an electrocardiogram, ECG, signal (); receiving () an artery signal () representative of pressure pulse wave propagation at a location in an artery; determining () a fiducial point in time based on the ECG signal () providing an indication of onset of isovolumetric contraction; determining () a pre-systolic pressure pulse arrival point in time () based on the artery signal () to correspond to the onset of the isovolumetric contraction being reflected in the artery signal (), determining () a time period between the onset of the isovolumetric contraction and the pre-systolic pressure pulse arrival point in time, said time period representing a vascular transit time; and determining () a pulse wave velocity of the subject () based on a physical distance between an aortic valve and the location in the artery and on the vascular transit time.

Method and a system for estimating a measure of cardiovascular health of a subject

A device for calculating a subject's cardiac pulse transit or arrival time information is configured to receive an electronic audio signal with information indicative of a human voice signal and a primary cardiac pulse signal; generate a power spectral profile of a section of the electronic audio signal, and detect a fundamental frequency (F) of the generated power spectral profile; generate a denoised audio signal; generate a time-domain intermediate signal that captures frequency, amplitude and/or phase of the denoised audio signal; detect at least one intermediate signal fiducial point, within a human cardiac band, in the intermediate signal; detect at least one primary cardiac pulse fiducial point, within a human cardiac band, in the primary cardiac pulse signal; calculate pulse transit time or pulse arrival time information between the at least one detected primary cardiac signal fiducial point and the at least one detected intermediate signal fiducial point.

System and method for calculating cardiac pulse transit or arrival time information

The present invention provides a method () for determining at least one parameter related to the microcirculation function of a person, said method comprising the steps of a) determining () an arrival time (AT) of a pulse wave, wherein the AT is the time between the onset of an activity of the heart producing said pulse wave and the arrival of said pulse wave in a part of the body of said person; b) varying () an applied pressure (P) on said part of the body over time and determining said AT as a function of applied pressure and time; and c) assessing () said at least one parameter related to the microcirculation function based on said determination of AT and said AT as a function of applied pressure and time in steps a) and b). The present invention further provides a system () for determining at least one parameter.

Method and system for determining a parameter related to microcirculation function

A device for calculating cardiovascular heartbeat information is configured to receive an electronic audio signal with information representative of a human voice signal in the time-domain, the human voice signal comprising a vowel audio sound of a certain duration and a fundamental frequency; generate a power spectral profile of a section of the electronic audio signal, and detect the fundamental frequency (F) in the generated power spectral profile; filter the received audio signal within a band around at least the detected fundamental frequency (F) and thereby generating a denoised audio signal; generate a time-domain intermediate signal that captures frequency, amplitude and/or phase of the denoised audio signal; detect and calculate heartbeat information within a human cardiac band in the intermediate signal.

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Soerendonk, Netherlands

Evelien Hermeling