Calcimedica, Inc.

Turning Point Therapeutics, Inc.

Tp Therapeutics, Inc.

Aurora Operations, Inc.

Blackmore Sensors & Analytics, LLC

Calcimedia, Inc.

Evan W Rogers

Jianguo Cao

Jeffrey Paul Whitten

Zhijun Wang

Jonathan Bryant Grey

Jingrong Jean Cui

Dayong Zhai

Yazhong Pei

Brian Dyck

Wei Deng

Jane Ung

Yishan Li

Gonul Velicelebi

Kenneth Stauderman

Han Zhang

Zhongdong Huang

Jeffrey Whitten

Zeb William Barber

Jing Liu

Xin Zhang

Ryan Moore Galloway

Sean Spillane

Vivian Nguyen

Andrew Steil Michaels

Edward Joseph Angus

Andy Michaels

Kenneth A Stauderman

Jingrong J Cui

The present invention relates to certain diaryl macrocyclic compounds, pharmaceutical compositions containing them, and methods of using them, including methods for treating cancer, pain, neurological diseases, autoimmune diseases, and inflammation.

Diaryl macrocycles as modulators of protein kinases

A light detection and ranging (LIDAR) system includes a transmitter, a first receiver, a second receiver, and one or more processors. The transmitter is configured to output a transmit beam. The first receiver is positioned on a first side of the transmitter and is configured to receive a first component of a return beam from reflection of the transmit beam by an object. The second receiver is positioned on a second side of the transmitter and is configured to receive a second component of the return beam. The one or more processors are configured to determine at least one of a range to the object or a velocity of the object and control operation of the autonomous vehicle based on the at least one of the range or the velocity.

Systems and methods for LIDAR sensor systems with high resolution scanning

This disclosure relates to the use of certain diaryl macrocycle compounds, specifically (7S13R)-11-fluoro-7,13-di-methyl-6,7,13,14-tetrahydro-1,15-ethenopyrazolo[4,3-f][1,4,8,10]benzoxatriazacyclotridecin-4(5H)-one in the treatment of disease in mammals. This disclosure also relates to compositions including such compounds, and to methods of using such compositions in the treatment of diseases in mammals, especially in humans.

Chiral diaryl macrocycles and uses thereof

This disclosure relates to polymorphs of (7S,13R)-11-fluoro-7,13-dimethyl-6,7,13,14-tetrahydro-1,15-ethenopyrazolo[4,3-f][1,4,8,10]benzoxatriazacyclotridecin-4(5H)-one that are useful in the treatment of disease, such as cancer, in mammals. This disclosure also relates to compositions including such polymorphs, and to methods of using such compositions in the treatment of diseases, such as cancer, in mammals, especially in humans.

Diaryl macrocycle polymorph

The present disclosure relates to certain macrocyclic compounds that inhibit SRC and MET, and/or CSFR, pharmaceutical compositions containing such compounds, and methods of using such compounds to treat cancer.

Macrocyclic compounds and uses thereof

Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.

Compounds that modulate intracellular calcium

A light detection and ranging (LIDAR) sensor system for a vehicle includes a transmitter, a receiver, and a scanner. The transmitter is configured to output a transmit beam. The transmitter includes a first grating coupler. The receiver includes a plurality of second grating couplers spaced apart from the first grating coupler.

LIDAR sensor system

A light detection and ranging (LIDAR) system for a vehicle includes a transmitter, a receiver, one or more scanning optics, and a circulator. The transmitter is configured to output a transmit beam. The receiver includes a first receive grating coupler and a second receive grating coupler. The circulator is configured to receive the transmit beam and provide the transmit beam to the one or more scanning optics, receive a return beam from reflection of the transmit beam by an object, split the return beam into at least a first component and a second component, and direct the first component to the first receive grating coupler and the second component to the second receive grating coupler.

The present disclosure relates to certain chiral diaryl macrocyclic derivatives, pharmaceutical compositions containing them, and methods of using them to treat cancer.

Macrocycles for use in treating disease

A light detection and ranging (LIDAR) system includes a laser, a transceiver, and one or more optics. The laser source is configured to generate a beam. The transceiver is configured to transmit the beam as a transmit signal through a transmission waveguide and to receive a return signal reflected by an object through a receiving waveguide. The one or more optics are external to the transceiver and configured to optically change a distance between the transmit signal and the return signal by displacing one of the transmit signal or the return signal.

Providing spatial displacement of transmit and receive modes in lidar system

The present disclosure relates to certain macrocyclic compounds that inhibit SRC and MET, and/or CSF1R, pharmaceutical compositions containing such compounds, and methods of using such compounds to treat cancer.

The present disclosure relates to certain macrocyclic derivatives, pharmaceutical compositions containing them, and methods of using them to treat disease, such as cancer.

Growing community of inventors

San Diego, CA, United States of America

Evan W Rogers