Leland Stanford Junior University

Agilent Technologies, Inc.

Evan P Thrush

James S Harris, Jr

Ofer Levi

Douglas Michael Baney

Gregory Douglas VanWiggeren

Krishna V Shenoy

Michael David McGehee

Stephen J Smith

Jonathan Ziebarth

Stepehn J Smith

Characteristics of biological substances, such as cerebral cortex matter, are sensed. According to an example embodiment, the present invention is directed to a negligibly-intrusive, multi-layer integrated circuit arrangement for monitoring activity of an area of a cerebral cortex that would normally be covered by an anatomical layer. The multi-layer integrated circuit arrangement includes an optics layer located outside the cerebral cortex area that includes an emitter and a detector. The optics layer is adapted for implantation in the anatomical layer and for sensing at least one brain-activity parameter. The multi-layered integrated circuit arrangement also includes a data-processing layer that includes a digital-processing circuit that is adapted for assimilating neural data in response to the optics layer sensing at least one brain-activity parameter.

Implantable sensing arrangement and approach

The use of a high power and an incoherent light source to reduce noise associated when investigating unknown molecules in Surface Plasmon Resonance (SPR) systems. High power and incoherent light sources can improve resolution and accuracy of SPR system measurements.

Optical sources for SPR applications

A variety of types of molecules are detected and/or analyzed using an integrated micro-circuit arrangement. According to an example embodiment of the present invention, a micro-circuit arrangement detects excitable target markers in response to an excitation source. The excitation source emits a first electromagnetic radiation to excite one or more target markers into emitting a second electromagnetic radiation. The excitation source and detector combination can be optimized to detect a specific characteristic of a biological specimen. In this manner, an excitation source can be combined with several optical-detectors or detection channels, where each optical-detector is measuring or sensing the same or different characteristic of the biological specimen.

Excitable target marker detection

An optical imaging system having an optical source located between the object being imaged and the sensor is provided. Such positioning of the source enables provision of compact optical imaging systems. In particular, such systems can have image widths significantly larger than the object to sensor separation. The arrangement of source, imaging assembly and sensor is such that an image of the source is not formed at the sensor. Therefore, the effect of this source positioning on the image of the object at the sensor is a reduction of intensity, as opposed to more objectionable imaging artifacts, such as spurious shadows and/or bright spots. Thus compact optical imaging systems having good image quality are provided, which enables high-fidelity imaging of object to sensor for a wide variety of applications.

Optical imaging system having an illumination source between object and image

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Evan P Thrush