Johns Hopkins University

Rutgers, the State University of New Jersey

Evan P Lloyd

Craig Arthur Townsend

Zhiyong Xia

Gyanu Lamichhane

Joel S Freundlich

Sean Ekins

Nicole M Parrish

Vanessa D Alphonse

Amit Kaushik

Pankaj Kumar

Shaogang Li

Strain sensing compositions including a polymeric matrix material and a mechanophore component distributed throughout the polymeric material and covalently bonded to the polymeric material are provided. The mechanophore component undergoes a visible color change and the strain sensing composition exhibits a continuous three-dimensional (3D) spatial strain distribution including at least one color gradient upon direct or indirect impact by an object. Methods of forming strain sensing compositions are also provided. Methods of evaluating a strain distribution associated with an impact of a surrogate material comprising a mechanophore component are also provided.

Strain sensing compositions

Antibacterial agents against D,D- and L,D-transpeptidases are disclosed. Pharmaceutical compositions and methods of using the same also are disclosed.

Antibacterial agents against D,D- and L,D-transpeptidases

New antimicrobials targeting L,D-transpeptidases, non-classical cysteine peptidases, have been developed and their unique chemical structures identified. Carbapenems and penems of the present invention are unique among &#x3b2;-lactams as they acylate and inhibit L,D-transpeptidases, which likely results in their superior antimicrobial potency. These new antimicrobial agents can be used alone, or in combination with other classic antimicrobial agents that target D,D transpeptidases, when treating bacterial infections.

Inhibitors of bacterial growth

Growing community of inventors

Ellicott City, MD, United States of America

Evan P Lloyd