University of Arizona

Teijin Limited

University of Texas System

Arizona Board of Regents, a Body Corporate

Hybritech Incorporated

Amplimed, Inc.

Evan M Hersh

Yasuhiko Masuho

Eugene W Gerner

David T Harris

Toru Sugano

Takashi Kawamura

Eskild A Petersen

Yoh-Ichi Matsumoto

Douglas Lake

Gabriel Lopez-Berestein

Kapil Mehta

Reeta Mehta

Rudolph L Juliano

Roy L Hopfer

Tom C Tsang

Victor Fainstein

Victor J Hruby

Michael G Rosenblum

Robert T Dorr

Jordan U Gutterman

Sydney E Salmon

William A Remers

James M Frincke

Tom Tsang

Thomas Chun-Chang Tsang

Karen G Burnett

Farha Vasanwala

Barbara W Unger

Bhashyam Iyengar

Eskild A Peterson

Yoh-ichi Matsumoto

Kit Sang Lam

Fahad Al-Obeidi

Methods and compositions are provided for transgene expression in target cells. Expression constructs using an inducible amplification system to drive expression of a therapeutic gene or other gene of interest in mammalian host cells are provided, as well as methods therefor. Inducible expression of the transgenes at high levels under physiologic conditions results from induction by hyperthermic conditions relative to the basal temperature of the host cells.

Hyperthermic inducible expression vectors for gene therapy and methods of use thereof

Expression constructs using an inducible amplification system to drive expression of a therapeutic gene or other genes of interest in mammalian cells are provided, as well as methods of using the same.

The present invention relates to inducible gene expression constructs and methods of inducing gene expression using a combination of inducing agents.

Inducible expression vectors and methods of use thereof

The present invention is directed to novel anti-cancer compounds of the formula.

Cyanoaziridines for treating cancer

Human monoclonal antibodies which belong to the IgGl subclass and are specific for HIV are described. The monoclonal antibodies have potential for use in the diagnosis, prevention and therapy of HIV infection.

Monoclonal antibodies specific for HIV and the hybridomas for production

Human monoclonal antibodies which belong to the IgG1 subclass and are specific for HIV are described. The monoclonal antibodies have potential for use in the diagnosis, prevention and therapy of HIV infection.

Human IgG1 monoclonal antibodies are produced by hybridoma ATCC HB10074 and bind to gp120 of HIV.

Monoclonal antibodies specific for HIV and hybridomas for their

The invention is directed to the human hybridoma designated MCA 86 and having A.T.C.C. Accession No. HB 9669 and human monoclonal antibodies produced by hybridoma MCA 86. Human monoclonal antibodies produced by hybridoma MCA 86 immunologically binds to both gp41 and gp120 envelope glycoproteins of Human Immunodeficiency Virus (HIV). These monoclonal antibodies are useful in the diagnosis of HIV infection.

Human hybridomas and monoclonal antibodies which bind both gp41 and

A complex of alpha-interferon with a monoclonal antibody complexes with the alpha-interferon without impairing its antiviral activity. The serum half-life of the interferon administered as the complex is substantially increased when compared to that of alpha-interferon administered alone.

Interferon antibody therapeutic compositions having an extended serum

A method is disclosed for treatment of disseminated fungal infection in a mammal comprising the administration of a fungicidally effective amount of Amphotericin B encapsulated in a substantially sterol-free liposome to the infected mammal. Also provided is an agent for treatment of disseminated fungal infection in a mammal comprising Amphotericin B encapsulated in a liposome which consists essentially of lipids other than sterols.

Composition and method for treatment of disseminated fungal infections

Method for treatment of disseminated fungal infection in a mammal comprising the administration of a fungicidally effective amount of Amphotericin B encapsulated in a substantially sterol-free liposome to the infected mammal. Also provided is an agent for treatment of disseminated fungal infection in a mammal comprising liposome-encapsulated Amphotericin B, said liposome being comprised of lipids other than sterols.

Growing community of inventors

Tucson, AZ, United States of America

Evan M Hersh