International Business Machines Corporation

Cornell Research Foundation Inc.

Globalfoundries Inc.

Evan G Colgan

Paul William Coteus

Gareth Geoffrey Hougham

Stefano Sergio Oggioni

Brian Samuel Beaman

Jeffrey Allen Zitz

Thomas J Brunschwiler

Robert L Wisnieff

John Harold Magerlein

Michael A Gaynes

Paul Stephen Andry

Stanislav Polonsky

John Ulrich Knickerbocker

Minhua Lu

Fuad Elias Doany

Michael J Ellsworth, Jr

Bucknell Chapman Webb

Russell Alan Budd

Hilton T Toy

Bruce Kenneth Furman

Lawrence Shungwei Mok

Raschid Jose Bezama

Timothy Joseph Chainer

Kenneth Parker Rodbell

Mark Delorman Schultz

Shurong Tian

Madhusudan K Iyengar

Roger R Schmidt

Sampath Purushothaman

Masaru Suzuki

Pritish Ranjan Parida

Kamal Kumar Sikka

Leland Chang

Christopher Vincent Jahnes

Jae-Woong Nah

Roy Rongqing Yu

Joel Abraham Silberman

Thomas Mario Cipolla

Takatoshi Tsujimura

James L Speidell

Shawn Anthony Hall

Rama Nand Singh

Michael Alan Schappert

Robert E Simons

Richard C Chu

Levi A Campbell

Milnes P David

Joshua T Smith

John Peter Karidis

Jeffrey Donald Gelorme

Da-Yuan Shih

Benjamin H Wunsch

Chandrasekhar Narayan

Sung Kwon Kang

Cornelia K Tsang

Daniel Michael Kuchta

Steven Paul Ostrander

James F White

Shui-Chih Alan Lien

Chirag Suryakant Patel

Xiaojin Wei

Jeffrey P Gambino

Casimer M DeCusatis

Alfred Grill

Cyril Cabral, Jr

Reinaldo Ariel Vega

Alan Edward Rosenbluth

Lubomyr Taras Romankiw

John G Torok

Lawrence Jacobowitz

Yoichi Taira

Katsuyuki Sakuma

Stephen L Buchwalter

David L Edwards

Li-Wen Hung

Gary Franklin Goth

Leathen Shi

Frank Louis Pompeo

William James Anderl

Subhash Laxman Shinde

Eisuke Kanzaki

James M Harper

Mukta G Farooq

William Louis Brodsky

Peter Alfred Gruber

Eugene John O'Sullivan

Robert J Von Gutfeld

Frank Robert Libsch

Benjamin V Fasano

David Brian Stone

Layne A Berge

Alan Frederic Benner

Edward Joseph Seminaro

Satoshi Maruyama

Gerard McVicker

Mareva B Fevre

How Tzu Lin

Wiren Dale Becker

Mark C H Lamorey

Toshiaki Arai

A method for fabricating a fluidic device includes depositing a sacrificial material on a pillar array arranged on a substrate. The method also includes removing a portion of the sacrificial material. The method further includes depositing a sealing layer on the pillar array to form a sealed fluidic cavity.

Fluidic cavities for on-chip layering and sealing of separation arrays

Techniques for quantitative colorimetric liquid analysis with color and turbidity correction are provided. In one aspect, an optical detector includes: a vessel for containing a liquid sample; a light source on a first side of the vessel; a first sensor on a second side of the vessel opposite the first side and along a light path of the light source; and a second sensor on a third side of the vessel at an angle &#x3b8; with respect to the light path. A method for quantitative measurement of an analyte is also provided, as is a method for color and turbidity analysis.

Optical sensor system for quantitative colorimetric liquid analysis

A method and apparatus for bonding a processor wafer with a microchannel wafer/glass manifold to form a bonded wafer structure are provided. A glass fixture is also provided for protecting C4 solder bumps on chips disposed on the processor wafer. When the glass fixture is positioned on the processor wafer, posts extending from the glass fixture contact corresponding regions on the processor wafer devoid of C4 solder bumps, so that the glass fixture protects the C4 solder bumps during wafer bonding. The method involves positioning the processor wafer/glass fixture and the microchannel wafer/glass manifold in a metal fixture having one or more alignment structures adapted to engage corresponding alignment elements formed in the processor wafer, glass fixture and/or glass manifold. The metal fixture secures the wafer components in place and, after melting solder pellets disposed between the processor wafer/glass fixture and microchannel wafer/glass manifold, a bonded wafer structure is formed.

Method and apparatus of processor wafer bonding for wafer-scale integrated supercomputer

A data processing system includes a first wafer comprising a plurality of first chips, and kerf and crack-stop structures around perimeters of the first chips, and a second wafer comprising a plurality second chips, a plurality of interconnect structures through a connection zone between the second chips, and a plurality of thru silicon vias, wherein the first wafer and the second wafer are bonded face-to-face such that the interconnect structures of the second wafer electrically connect adjacent chip sites of the first wafer and where a pitch of the chips on the first and second wafer are equal.

Wafer scale supercomputer

Techniques for colorimetric based test strip analysis and reader system are provided. In one aspect, a method of test strip analysis includes: illuminating a test strip wetted with a sample with select spectrums of light, wherein the test strip includes test pads that are configured to change color in the presence of an analyte in the sample; obtaining at least one digital image of the test strip; and analyzing color intensity from the at least one digital image against calibration curves to determine an analyte concentration in the sample with correction for one or more interference substances in the sample that affect the color intensity. A calibration method and a reader device are also provided.

Accurate colorimetric based test strip reader system

An apparatus having a spectrometer and techniques for use thereof for efficient and effective point-of-care diagnostics are provided. In one aspect, a device is provided. The device includes: an intake port; fluidic channels connecting the intake port to a detecting chamber(s), wherein the detecting chamber(s) is configured to permit optical measurements of a fluid sample; a vent leading away from the detecting chamber(s); and a liquid blocker between the detecting chamber(s) and an opening of the vent, wherein the liquid blocker permits air to pass therethrough while at the same time restricting liquid flow. A method for analyzing a fluid sample is also provided. The method includes: introducing the fluid sample to the device; contacting the fluid sample with a reagent(s) prior to the fluid sample entering the detecting chamber(s); and making optical measurements of the fluid sample in the detecting chamber(s).

Analysis apparatus with spectrometer

Systems, computer program products, and methods for using a flow cell array are provided herein. A computer program product includes a computer readable storage medium having program instructions embodied therewith, the program instructions executable by a device to cause the device to determine placement of multiple reaction site openings, wherein each reaction site opening is connected to a first sub-surface channel; connect the first sub-surface channel to two or more additional sub-surface channels by multiple vias; and provide a material for multiple reaction sites, wherein an overlap of the multiple reaction site openings and the material delineate the multiple reaction sites.

Imaging multiple chemical reactions in a flow cell array

Apparatus, computer program products, and methods for using a flow cell array are provided herein. A computer program product includes a computer readable storage medium having program instructions embodied therewith, the program instructions executable by a device to cause the device to determine placement of one or more reaction sites on a first component; provide a material for the reaction sites in one or more surface channels of the first component; connect the first component to a second component to form an array, wherein the surface channels of the first component connect the reaction sites with one or more vias, and wherein the second component comprises the vias connected to multiple sub-surface channels; and align the surface channels of the first component with the vias of the second component to form a connection between the first component and the second component.

Systems, computer program products, and methods for using a flow cell array are provided herein. A system includes at least one processor coupled to a memory and configured for determining placement of multiple reaction site openings, wherein each reaction site opening is connected to a first sub-surface channel; connecting the first sub-surface channel to two or more additional sub-surface channels by multiple vias; and providing a material for multiple reaction sites, wherein an overlap of the multiple reaction site openings and the material delineate the multiple reaction sites.

Systems, computer program products, and methods for using a flow cell array are provided herein. A system includes at least one processor coupled to a memory and configured for delivering multiple items of chemical matter independently to multiple reaction sites of a flow cell array across multiple distinct instances of time; imaging multiple parallel chemical reactions at the multiple reaction sites of the flow cell array; and recording an emission from each of the multiple chemical reactions site.

Recording emission from multiple chemical reactions sites in a flow cell array

Systems and methods for using a flow cell array are provided herein. A system includes at least one processor coupled to a memory and configured for determining placement of one or more reaction sites on a first component; providing a material for the one or more reaction sites in one or more surface channels of the first component; connecting the first component to a second component to form an array, wherein the one or more surface channels of the first component connect the one or more reaction sites with one or more vias, and wherein the second component comprises the one or more vias connected to multiple sub-surface channels; and aligning the one or more surface channels of the first component with the one or more vias of the second component to form a connection between the first component and the second component.

Flow cell array and uses thereof

Systems, computer program products, and methods for using a flow cell array are provided herein. A computer program product includes a computer readable storage medium having program instructions embodied therewith, the program instructions executable by a device to cause the device to deliver multiple items of chemical matter independently to multiple reaction sites of a flow cell array across multiple distinct instances of time; image multiple parallel chemical reactions at the multiple reaction sites of the flow cell array; and record an emission from each of the multiple chemical reactions site.

Techniques for localized surface modification for microfluidic applications are provided. In one aspect, a method includes: contacting at least one portion of a surface with at least one tri(m)ethoxysilane-containing solution under conditions sufficient to form at least one silane monolayer having a given contact angle on the surface thereby modifying a flow rate over the surface. The silane monolayer can include a silane derivative selected from: trimethoxysilyl-propoxypolyethyleneoxide (TMS-PPEO), hexadecyl-triethoxysilane (HD-TES), tridecafluoro-1,1,2,2-tetrahydrooctyl)triethoxysilane (TDF-THO-TES), and combinations thereof. A device modified in accordance with the present techniques is also provided.

Localized surface modification for microfluidic applications

Growing community of inventors

Chestnut Ridge, NY, United States of America

Evan G Colgan