Elan Pharma International Limited

Fournier Laboratories Ireland Limited

Ge Healthcare Limited

Amersham Plc

Alkermes Pharma Ireland Limited

Bgp Products Ireland Limited

Evan E Gustow

Tuula Ryde

Stephen B Ruddy

Rajeev A Jain

Rakesh A Patel

Michael John Wilkins

Robert A Snow

Gregory L McIntire

Edward R Bacon

Eugene Rex Cooper

Nigel Anthony Powell

Dewi M Lewis

Lucinda A Dollimore

Rajeev Jain

Rajeev c/o Elan Drug Delivery Jain

The present invention is directed to fibrate compositions having improved pharmacokinetic profiles and reduced fed/fasted variability. The fibrate particles of the composition have an effective average particle size of less than about 2000 nm.

Nanoparticulate fibrate formulations

The present invention is directed to nanoparticulate compositions comprising topiramate. The topiramate particles of the composition have an effective average particle size of less than about 2 microns.

Nanoparticulate topiramate formulations

Methods of treatment using nanoparticulate fenofibrate compositions

The invention provides the use of a radiation source which is a low energy X-ray emitter, e.g. with an energy of emission of the principal photon in the range of 20 to 100 keV, preferably 20 to 40 keV and with a half life of 10 to 100 days, preferably 15 to 70 days, for the treatment of restenosis. Suitable radioisotopes include palladium-103, dysprosium-159, samarium-145, cadmium-109, ytterbium-169 and preferably iodine-125. High activity radioactive bodies and sources comprising such radioisotopes, and methods for the manufacture of such sources, are also disclosed.

Apparatus and methods for radiotherapy

A method for the immobilization of a radioactive anion on the surface of a metal substrate, said method comprising treating the substrate with an oxidizing agent in the presence of a solution of a radioactive anion which forms an insoluble salt with ions of said metal. Preferably, a binding agent will also be present. Preferably, the metal is silver, the radioactive anion is I and the binding agent comprises bromide ions.

Method of coating a metal substrate with a radioactive layer

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Villanova, PA, United States of America

Evan E Gustow