Optopo Inc.

Duke University

Evan Christopher Cull

David Brady

Prasant Potuluri

John Edward Stranzl, Jr

Michael E Gehm

Mehran Ghofrani

Kenneth Wayne Chapman

A pharmaceutical solid in a prescription vial is identified from an optical property of the pharmaceutical solid using light reflected from two different light sources. For each known pharmaceutical solid, an optical property of the known pharmaceutical solid is stored. The prescription vial is illuminated with a first light source and a first image is recorded. The prescription vial is then illuminated with a second light source and a second image is recorded. The first image and the second image are processed to find an optical property of the pharmaceutical solid. The optical property found is compared to the stored optical properties. The identity of the pharmaceutical solid is determined from the comparison. The first light source and the second light source are selected to remove artifacts of the prescription bottle or to enhance or suppress two-dimensional or three-dimensional effects on the surface of the pharmaceutical solid.

Machine vision and spectroscopic pharmaceutical verification

The static MMS spectral reconstruction process is optimized using algorithmic methods. Because the static MMS encodes spectral information across the detector plane in a highly non-local way, optical errors have a non-local effect on the reconstruction which introduces noise and errors at regions throughout the spectral range. Mathematical signal processing techniques are used to condition and deconvolve the spectral image to compensate for non-ideal system behavior. Spectral signal-to-noise and accuracy are both improved, while the inherent resolution and etendue advantages of the static MMS technique are retained.

Method and apparatus for reconstructing optical spectra in a static multimode multiplex spectrometer

An optical spectrometer distinguishes ambiguity between different wavelength constituent components present in incident light. A spatial filter in the spectrometer spatially filters the incident light. A dispersion system receives the spatially filtered light and disperses images of the spatial filter in a wavelength dependent fashion such that two or more wavelength-specific images at least partially overlap at a detector system. The detector system comprises a detector array and processor that detects and processes the dispersed light to remove ambiguity between one or more of the overlapping images. The detector array may detect coded aperture images associated with a coded aperture spatial filter defined by a coded aperture function, and the processor may process the detector array output signals using an analysis function that complements the coded aperture function. The detector system may filter the spatial filter images and electronically process the resulting detector array output signals.

Optical spectroscopy with overlapping images

Growing community of inventors

Durham, NC, United States of America

Evan Christopher Cull