Roche Molecular Systems, Inc.

Roche Sequencing Solutions, Inc.

Evan Amato

Shawn Lee Suko

Aruna Ayer

Mara Boenitz-Dulat

Ilya Lederman

Eileen Thai

Charles Wayan Schwab

Cleoma Arnold

Colin Alexander McGaw

Barbara Eckert

Preethi Sarvabhowman

David Daniel Wunderlich

Bigna Woersdoerfer

The present disclosure provides variant Pol6 polymerase polypeptides, compositions comprising the Pol6 variant polypeptides, and methods for using the variant Pol6 polypeptides for determining the sequencing of nucleic acids, for example, by nanopore sequencing. The variant Pol6 polymerases possess decreased rates of dissociation of template from the polymerase-template complex, which result in increased processivity relative to the parental Pol6 polypeptides from which they are derived.

Pol6 polymerase variants

Polymerase variants

Growing community of inventors

Menlo Park, CA, United States of America

Evan Amato