Richter Gedeon Vegyeszeti Gyar Rt

Eva Udvardy-Nagy Nee Cserey Pechaany

Gabriella Kordik

Maria Trinn

Rzsebet Zsoka Nee Somkuti

Zsuzsanna Vida

The invention relates to a new microbiological process for the preparation of clavine alkaloids of the general formula (I), ##STR1## wherein R stands for hydroxymethyl or methyl group, by cultivation of a Claviceps fusiformis strain in liquid submerged culture medium containing sources of carbon, nitrogen, mineral salts and optionally other additives, under aerobic conditions, in which a Claviceps fusiformis variant strain deposited under No. 00211 is used as alkaloid-producing strain. The invention further relates to a biologically pure culture of the Claviceps fusiformis variant strain No. 00211 obtained in a process in which a Claviceps fusiformis strain No. 00164 is grown in a solid culture medium containing sources of carbon, nitrogen, mineral salts and agar as well as an additive promoting the formation of cytochrome P-450, followed by the selective isolation of the new strain No. 00211.

Growing community of inventors

Budapest, Hungary

Eva Udvardy-Nagy Nee Cserey Pechaany