Egis Gyogyszergyar Zrt.

Egis Gyogyszergyar

Eva Szabo

Balazs Volk

Gyula Simig

Gabor Gigler

Frigyes Gorgenyi

Jozsef Reiter

Zoltán Varga

Pal Fekete

Peter Tompe

László Szlávik

Istvan Ling

Péter Trinka

Margit Csorgo

Gyorgyi Kovanyine Lax

Andras Dancso

Enikó Molnár

Janos Brlik

Ilona Sztruhar

Peter Slegel

Janos Petho

Maria Kiraly Nee Ignacz

Gyorgy Jeges

Peter Gregor

Jeno Peter Seres

Agnes Halbauer Nee Nagy

Magdolna Kenyeres Nee Feher

Sarolta Benko Nee Markus

Szvetlana Zsarnoczai Nee Kurnyecova

Dezso Danyi

Judit Halasz

Marta Porcs-makkay

The present invention relates a new process for the preparation of ozanimod of the formula and acid addition salts, via new intermediates and a new polimop form of ozanimod base.

Process for the production of ozanimod

The invention relates to an improved process for the preparation of pharmaceutical active ingredients and also to high purity salts and pharmaceutical compositions prepared by said process. More particularly the invention relates to an economical process for the preparation of the compound having the international non-proprietary name (INN) vortioxetine and the chemical nomenclature 1-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]-piperazine. Vortioxetine corresponds to the following Formula  Still more particularly the invention relates to the preparation of high purity vortioxetine L-(+)-mandelate salt of the Formula IX, the conversion of this salt into other highly pure salts and also to the formulation of said salts.

Process for the preparation of vortioxetine salts

This invention relates to a new and improved process for the preparation of 6,7-dichloro-1,5-dihydroimidazo[2,1-b]-quinazolin-2[3H]-one of formula ##STR1## (anagrelide), a valuable blood platelet antiaggregative compound. According to the process of the invention the compound of formula (I) is prepared by subjecting a new 2-cyanoiminoquinazoline derivative of the general formula ##STR2## wherein R stands for cyano or a group of the formula COOR.sup.1, in the latter R.sup.1 representing lower alkyl optionally carrying a phenyl substituent, to thermal cyclization in an acidic medium. The invention also relates to new 2-cyanoiminoquinazo-lines of the general formula (III) used for the production of anagrelide and to the preparation of the said compounds. The invention provides an advantageous process for the preparation of anagrelide which is devoid of the drawbacks of the hitherto known processes and renders possible the production of the compound of the formula (I) on industrial scale, too.

Process for the preparation of

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Budapest, Hungary

Eva Szabo