Intrexon Corporation

Basf Se Corporation

Eva Rödel

Fritz Blatter

Andreas Hafner

Robert Eugene Hormann

Martin Szelagiewicz

Tobias Hintermann

Inna Shulman

Tiziana Chiodo

Rolf Hilfiker

Susan Margaret De Paul

Marcus Vossen

Beate Salvador

The present disclosure provides crystalline polymorphic and amorphous forms of (R)-3,5-dimethyl-benzoic acid N-(1-tert-butyl-butyl)-N'-(2-ethyl-3-methoxy-benzoyl)-hydrazide (Compound 1) or (S)-3,5-dimethyl-benzoic acid N-(1-tert-butyl-butyl)-N&#x2032;-(2-ethyl-3-methoxy-benzoyl)-hydrazide (Compound 2). The present disclosure further provides compositions comprising crystalline polymorphic and amorphous forms of Compound 1 or Compound 2 and an excipient, methods of making crystalline polymorphic or amorphous forms of Compound 1 or Compound 2, and methods of using crystalline polymorphic or amorphous forms of Compound 1 or Compound 2 to regulate gene expression in a cell or in a subject.

Crystalline diacylhydrazine and the use thereof

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Basel, Switzerland

Eva Rödel