Univerzita Palackeho V Olomouci

Ustav Organicke Chemie a Biochemie Av Cr, V.v.i.

Helmholtz Zentrum Munchen

Ustav Molekularni Genetiky Akademie Ved Cr, V.v.i.

Eva Prchalova

Marian Hajduch

Petr Dzubak

Jerzy Adamski

David Sedlak

Petr Bartunek

Gabriele Moeller

Martin Kotora

Ondrej Stepanek

15&#x3b2;-substituted derivatives of estrone of general formula I wherein R, R, R, R, Rare independently selected from the group consisting of: C-Calkyl, C-Calkoxy, C-Chalogenalkyl, halogen, COORwherein Ris C-Calkyl; H, OH; optionally, R, Rand Rare each formed by a hydrogen atom, while Rand Rtogether form an aryl group, preferably naphthyl, in which the aromatic ring in position C-15 can be mono-, di-, tri-, tetra- and penta-substituted with substituents R-R. Compounds of the invention may be used for diagnosis and possibly also for the treatment of estrogen-dependent diseases.

15&#x3b2;-substituted estrone derivatives as selective inhibitors of 17&#x3b2;-hydroxysteroid-dehydrogenases, method of preparation and use thereof

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Eva Prchalova